临床眼科杂志2023，Vol.31Issue(6)：514-519,6.DOI:10.3969/j.issn.1006-8422.2023.06.007
雷珠单抗联合地塞米松缓释剂对糖尿病性白内障术后黄斑水肿的预防及视网膜、脉络膜厚度的影响
Effect of Ranibizumab combined with dexamethasone sustained release on the prevention of macular edema and the thickness of retina and choroid after diabetic cataract surgery
黄鸣宇 1罗昊敏 1段国平1
作者信息
- 1. 41000长沙,湖南省人民医院(湖南师范大学附属第一医院)眼一科
- 折叠
摘要
Abstract
Objective To investigate the effect of Ranibizumab combined with dexamethasone sustained release on the prevention of macular edema after diabetic cataract surgery and the thickness of macular fovea retina and choroid thick-ness under macular fovea.Methods Prospective single-center randomized study.Participants A total of 112 patients(134 eyes)with diabetic cataract were admitted to our hospital.112 patients were divided into study group(56 cases)and con-trol group(56 cases)by random number table method.Both groups were treated with phacoemul sification combined with intraocular lens implantation.The control group received intravitreal injection of dexamethasone sustained release agent,and the study group received intravitreal injection of Ranibizumab on the basis of the control group.The average best cor-rected visual acuity(BCVA),macular foveal retinal thickness,macular volume,macular edema and subfoveal choroidal thickness before and after operation were compared between the two groups.Results There was no significant difference in preoperative baseline data between the two groups(all P＞0.05).Repeated measurement ANOVA results showed that the mean BCVA,macular foveal retinal thickness,macular total volume and macular subfoveal choroid thickness of the two groups were statistically significant at different time points after surgery(all P＜0.05),and the differences among different groups were statistically significant(all P＜0.05).There was an interaction between different time and groups(all P＜0.05),and all indexes in the study group were lower than those in the control group(all P＜0.05).The total incidence of macular edema in the study group(10 cases,17.86％)was significantly lower than that in the control group(31 cases,55.36％)(P＜0.05).There were no adverse drug reactions in the two groups.Conclusions Ranibizumab combined with dexamethasone sustained release agent can reduce the incidence of macular edema after diabetic cataract surgery,and slow down the increase of macular fovea retinal thickness and the thickness of the choroid under macular fovea,which is helpful for postoperative visual recovery of the affected eye.关键词
糖尿病性白内障/雷珠单抗/黄斑水肿/黄斑中心凹视网膜厚度/黄斑中心凹下脉络膜厚度Key words
Diabetic cataract/Ranibizumab/Macular edema/Macular foveal retinal thickness/Subfoveal choroidal thickness引用本文复制引用
黄鸣宇,罗昊敏,段国平..雷珠单抗联合地塞米松缓释剂对糖尿病性白内障术后黄斑水肿的预防及视网膜、脉络膜厚度的影响[J].临床眼科杂志,2023,31(6):514-519,6.
