西南医科大学学报2024，Vol.47Issue(1)：20-24,5.DOI:10.3969/j.issn.2096-3351.2024.01.005
粪菌移植治疗炎症性肠病的研究进展
Progress of fecal bacteria transplantation in the treatment of inflammatory bowel disease
摘要
Abstract
Inflammatory bowel disease(IBD)is a group of chronic non-specific diseases characterized by intestinal inflamma-tion and mucosal damage,including ulcerative colitis(UC)and Crohn's disease(CD).The etiology of IBD is complex,and the patho-genesis has not yet been fully clarified.However,it is generally believed that the interaction among genetic,environmental,immune and other factors are the main reasons for the occurrence and development of IBD.With the deepening of research,it is found that intestinal flora dysbiosis and intestinal mucosal barrier damage also play an important role in the progress of IBD.The conventional medical treat-ment of IBD often has limited efficacy and is prone to major adverse reactions.Therefore,in recent years,new treatment methods for IBD,including fecal microbiota transplantation(FMT),aimed at regulating intestinal microbiota,have attracted extensive attention.In this review,the pathogenesis of IBD,the importance of flora to organism,the relationship between the flora and IBD,the mechanism of FMT and the effectiveness and safety of FMT in the treatment of inflammatory bowel disease will be summarized,in an attempt to pro-vide some reference for the individualized treatment of inflammatory bowel disease with FMT in the future.关键词
炎症性肠病/溃疡性结肠炎/克罗恩病/肠道菌群/粪菌移植Key words
Inflammatory bowel disease/Ulcerative colitis/Crohn's disease/Intestinal flora/Fecal bacteria transplantation分类
医药卫生引用本文复制引用
叶雨松,周雪芹,颜琼,钟晓琳,吕沐瀚..粪菌移植治疗炎症性肠病的研究进展[J].西南医科大学学报,2024,47(1):20-24,5.基金项目
国家自然科学基金(81972296) （81972296）
四川省科技计划项目(2021JDTD0003) （2021JDTD0003）
