西南医科大学学报2024，Vol.47Issue(1)：80-86,7.DOI:10.3969/j.issn.2096-3351.2024.01.016
低氧条件下HIF-1α对骨生理中成骨和破骨的影响
Effects of HIF-1α on osteogenesis and osteoblastogenesis in bone physiology under hypoxic conditions
摘要
Abstract
Bone resorption,formation and homeostasis maintenance are based on osteogenic and osteoclastic phenomenon,which include the regulation of a variety of factors.HIF-1α,as a marker of hypoxia,has been confirmed participating in a variety of process related to osteogenesis and osteoclast.And various vivo and in vitro hypoxia models have further revealed that HIF-1α can regulate bone physiology.These studies provide direct or indirect evidence that HIF-1α regulates osteogenic and osteoclastic events,but the ef-fects of HIF-1α on osteogenesis and osteoclasty have not been systematically summarized.This review summarized the mechanism of regulation of HIF-1α on osteogenesis and osteoclasty and its participation in relevant clinical events.HIF-1α directly participates in os-teogenesis and osteoclasty mainly through combing with the hypoxia response element(HRE)of osteogenesis related gene and osteoclast related gene under hypoxia.In addition,HIF-1α can also achieve the energy demand of osteogenic and osteoclastic events by enhancing glycolysis.But at the same time,the acidified environment will further stimulate the actvition of osteoclasts.Through the above review,we found that the two different events of osteogenesis and osteoclast regulated by HIF-1α may be closely related to the duration and con-centration of hypoxia,and the acidification degree of glycolysis under different oxygen conditions,mediated by HIF-1α,may be the key factors that determine the trend of osteogenesis and osteoclast.We believe that hypoxia duration,as a part of"hypoxia dose",should have an important impact on bone physiology,which needs more attention in future research.At the same time,in the state of continuous hypoxia,the transformation of HIF subtypes is also worthy of more in-depth study on the impact of bone physiology.Therefore,this ar-ticle focuses on the effect of HIF-1αon osteogenesis and osteoclasis process under hypoxia,and provide a theoretical basis for the regu-lation mechanisms of bone physiological changes under hypoxia.关键词
低氧/缺氧诱导因子-1α/成骨/破骨Key words
Hypoxia/HIF-1α/Osteogenesis/Osteoclastic分类
医药卫生引用本文复制引用
范智博,魏绵兴,李胜鸿,徐晓梅..低氧条件下HIF-1α对骨生理中成骨和破骨的影响[J].西南医科大学学报,2024,47(1):80-86,7.基金项目
四川省科技厅科技计划联合创新专项项目(2022YFS0634-B3) （2022YFS0634-B3）
四川省医学会项目(S23016) （S23016）
