日用化学品科学2024，Vol.47Issue(1)：41-47,7.DOI:10.3969/j.issn.1006-7264.2024.01.008
玫瑰/鸢尾/百合活性组合物基于婴儿3D皮肤模型的保湿及促屏障功能的功效研究
Study on the moisturizing and barrier promoting effects of rose/iris/lily active composite based on 3D baby skin model
胡雅文 1龚婷 1刘畅 1李英1
作者信息
- 1. 上海嗳乐蓓贝婴童用品有限公司,上海 201400
- 折叠
摘要
Abstract
The effects of a combination of rose/iris/lily active ingredients on the skin barrier function and water content were investigated by using a unique 3D full-thickness reconstructed baby skin model.The influence of treatments with active ingredients on the moisturizing and barrier function of baby skin model was investigated,in which the histological and immunobiological analyses of filaggrin,claudin-1,caspase-14 and hyaluronic acid were performed.Compared with the adult reconstructed skin,the reconstructed baby skin showed a thinner epidermis with smaller corneocytes,which validated that the constructed 3D baby skin model could simulate the structure of human skin very well,and it was of scientific significance to use this model for efficacy testing.For the 3D baby skin model treated with the combination(at a concentration of 0.005%)of rose/iris/lily active ingredients,the expression of filaggrin,claudin-1 and caspase-14 was significantly increased by 190.5%,224.5%and 135.0%,respectively.Therefore,this composite displayed the potential to be applied in cosmetics for infants,children,and sensitive skin.关键词
3D皮肤模型/婴童皮肤/活性成分组合物/保湿Key words
3D skin model/infant skin/active ingredient combination/moisturizing分类
化学化工引用本文复制引用
胡雅文,龚婷,刘畅,李英..玫瑰/鸢尾/百合活性组合物基于婴儿3D皮肤模型的保湿及促屏障功能的功效研究[J].日用化学品科学,2024,47(1):41-47,7.
