四川中医2023，Vol.41Issue(11)：144-150,7.
结肠透析序贯中药保留灌肠对多囊肾CKD 4～5期患者血清炎症因子影响
Effect of sequential TCM retention enema on serum inflammatory factors in patients with polycystic kidney disease Stage 4-5
摘要
Abstract
Objective:To investigate the effect of sequential TCM retention enema on serum inflammatory factors in patients with polycystic kidney disease stage 4-5.Method:A total of 90 patients with polycystic kidney disease(CKD stage 4-5)admit-ted to nephrology Department of Wuwei People's Hospital from April 2016 to April 2021 were selected as the study objects.Ac-cording to randomized control method,the patients were divided into experimental group(45 cases)and control group(45 ca-ses),and the control group received high level colon dialysis treatment.On the basis of the control group,the experimental group was followed by retention enema of traditional Chinese medicine(rhubarb,calcined oyster,dandelion,leonuri,calcined keel,aconite and licorice).All patients were treated for 8 weeks.Clinical efficacy,TCM symptom score,serum inflammatory index,immune function,renal function index,safety,adverse reaction of the two groups.Results:The total effective rate of experimental group was higher than that of control group(P＜0.05).Compared with before treatment,after treatment,the scores of traditional Chinese medicine symptoms such as yellow and weak face,floating face and swollen limbs,dizziness,waist and knee soreness and weakness,eating less and eating less,abdominal distension and vomiting,body weight and cloudy urine in the two groups were reduced(P＜0.05).Compared with control group,TCM symptom score of experimental group was lower(P＜0.05).Com-pared with before treatment,serum levels of IL-1β,hs-CRP,IL-6,TNF-α,IL-18 and TGF-β1 in 2 groups were decreased after treatment(P＜0.05).Compared with the control group,the serum inflammation level of experimental group was lower(P＜0.05).Compared with before treatment,lymphocyte count,neutrophil count and CD8+were decreased,while CD3+,CD4+and CD4+/CD8+were increased in 2 groups after treatment(P＜0.05).Compared with the control group,CD8+in experimental groups was lower,and CD3+,CD4+and CD4+/CD8+were higher(P＜0.05).After treatment,there were no significant differ-ences in lymphocyte count and neutrophil count between control group and experimental group(P＞0.05).Compared with before treatment,serum BUN,Scr and UAER levels were decreased and eGFR levels were increased in 2 groups after treatment(P＜0.05).Compared with the control group,the levels of BUN,Scr and UAER in experimental groups were lower,and the levels of eGFR were higher(P＜0.05).There were no significant differences in the levels of WBC,RBC,PLT,HGB,ALT and AST be-tween the two groups before and after treatment(P＜0.05).The adverse reactions of the experimental group were lower than those of the control group during treatment,and the difference was statistically significant(P＜0.05).Conclusion:It is proved that co-lon dialysis sequential retention enema with traditional Chinese medicine can significantly improve clinical symptoms,and its ther-apeutic mechanism may be related to regulating serum inflammatory factors and protecting renal function from damage,which is suitable for clinical application.关键词
结肠透析/中药保留灌肠/多囊肾CKD4～5期/血清炎症因子Key words
colon dialysis/Traditional Chinese medicine retention enema/Polycystic kidney CKD stage 4-5/Serum in-flammatory factor分类
医药卫生引用本文复制引用
陈建丽,万廷信,李洋,赵孟德..结肠透析序贯中药保留灌肠对多囊肾CKD 4～5期患者血清炎症因子影响[J].四川中医,2023,41(11):144-150,7.基金项目
武威市科技计划项目(编号:WW2002088). （编号:WW2002088）
