山东医药2024，Vol.64Issue(2)：13-17,5.DOI:10.3969/j.issn.1002-266X.2024.02.003
依达拉奉右莰醇在高龄中重度急性缺血性脑卒中rt-PA静脉溶栓治疗中的应用时机
Timing of edaravone dexborneol in intravenous thrombolysis with rt-PA for elderly patients with moderate to severe acute ischemic stroke
摘要
Abstract
Objective To investigate the timing of edaravone dexborneol in intravenous thrombolysis with recombi-nant tissue plasminogen activator(rt-PA)for elderly patients with moderate to severe acute ischemic stroke(AIS).Methods A total of 221 patients older than 80 years with moderate to severe AIS receiving intravenous thrombolysis with rt-PA were divided into the control group(70 cases received intravenous thrombolytic therapy with rt-PA),the early group(n=75,edaravone dexborneol began immediately after intravenous thrombolysis with rt-PA)and the late group(n=76,edaravone dexborneol started at 24 h after intravenous thrombolysis with rt-PA).The neurologic improvement rate at 7 days and good prognosis rate at 90 days were used to evaluate the efficacy.The short-term efficacy and long-term efficacy of the three groups were compared.The incidences of symptomatic intracranial hemorrhage within 24 h,extracranial compli-cations within 14 days and mortality within 90 days were observed,and the safety of the three groups was compared.Results The neurologic improvement rate at 7 days and the good prognosis rate at 90 days of the early group and the late group were higher than those of the control group,and those were higher in the early group than in the late group(all P<0.05).The incidences of symptomatic intracranial hemorrhage within 24 h and extracranial complications within 14 days in the early group were lower than those in the late group and control group(all P<0.05),while there were no statisti-cally significant differences between the late group and the control group(all P>0.05).The mortality rates within 90 days of the early and late groups were lower than that of the control group,and that was lower in the early group than in the late group(P<0.05).Conclusion Immediate application of edaravone dexborneol after intravenous thrombolysis with rt-PA is the optimal intervention time for elderly patients with moderate to severe AIS,which can promote the efficacy and safety,reduce complication rate and improve the prognosis of patients.关键词
依达拉奉右莰醇/静脉溶栓/急性缺血性脑卒中/组织型纤溶酶原激活剂Key words
edaravone dexborneol/intravenous thrombolysis/acute ischemic stroke/recombinant tissue plasmino-gen activator分类
医药卫生引用本文复制引用
谷亚伟,董银华,王利军,陈念,楚旭,赵路静,洪波,罗芝宽,林展增,李强,范宏光,高静珍..依达拉奉右莰醇在高龄中重度急性缺血性脑卒中rt-PA静脉溶栓治疗中的应用时机[J].山东医药,2024,64(2):13-17,5.基金项目
天津市卫生健康科技项目(ZC20073) （ZC20073）
天津市第四中心医院2022年度优秀青年人才培养基金(tjdszxyy20220012). （tjdszxyy20220012）
