山东医药2024，Vol.64Issue(2)：18-21,4.DOI:10.3969/j.issn.1002-266X.2024.02.004
3D pCASL不同标记后延迟时间评估急性缺血性脑卒中缺血半暗带体积时相对脑血流量阈值的选择
Selection of relative CBF threshold on 3D pCASL at different PLD for assessment of ischemic penumbra volume in acute ischemic stroke
黄川胜 1郑召龙 2李芹 2谢福才 1陈永升 2于海童 3牛庆亮4
作者信息
- 1. 山东中医药大学第一临床医学院,济南 250014
- 2. 潍坊市中医院影像中心
- 3. 山东第二医科大学医学影像学院
- 4. 潍坊市第二人民医院影像科
- 折叠
摘要
Abstract
Objective To explore the selection of relative cerebral blood flow(rCBF)threshold on 3D pseudo-con-tinuous arterial spin labeling(3D pCASL)at different post labeling delay(PLD)for assessment of ischemic penumbra vol-ume in acute ischemic stroke(AIS).Methods Forty-two patients with AIS underwent magnetic resonance imaging(MRI)conventional sequence imaging,3D pCASL imaging,and dynamic susceptibility contrast-perfusion weighted imag-ing(DSC-PWI).Image data of diffusion weighted imaging,3D pCASL and DSC-PWI were imported into F-stroke software for automatic analysis in order to generate ischemic penumbra volume of 3D pCASL and DSC-PWI.The ischemic penum-bra volume of DSC-PWI was taken as the reference standard,and intraclass correlation coefficient(ICC)was used to ana-lyze consistency between ischemic penumbra volume from rCBF<30%,40%,and 50%at PLDs of 1 525 ms and 2 525 ms.The difference between the ischemic penumbra volume from different rCBF thresholds and that from DSC-PWI was compared.Results The ischemic penumbra volume from rCBF<40%,50%at the PLD of 1 525 ms was consistent with that from DSC-PWI(ICC=0.595,0.791,all P<0.01).The ischemic penumbra volume from rCBF<50%at PLD of 2 525 ms was consistent with that from DSC-PWI(ICC=0.577,P<0.01).Ischemic penumbra volume from rCBF<40%at PLD of 1 525 ms was not significantly different from that from rCBF<50%at PLD of 2 525 ms(P>0.05).Conclusions Both PLDs of 1 525 ms and 2 525 ms based on 3D pCASL can be used for quantitative evaluation of ischemic penumbra vol-ume.The rCBF threshold of different PLD is different.The rCBF threshold should be selected as<50%at short PLD(1 525 ms),while the rCBF threshold at long PLD(2 525 ms)should be higher than that at short PLD(1 525 ms).关键词
三维伪连续动脉自旋标记/急性缺血性脑卒中/缺血半暗带/相对脑血流量Key words
3D pCASL/acute ischemic stroke/ischemic penumbra/relative cerebral blood flow分类
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黄川胜,郑召龙,李芹,谢福才,陈永升,于海童,牛庆亮..3D pCASL不同标记后延迟时间评估急性缺血性脑卒中缺血半暗带体积时相对脑血流量阈值的选择[J].山东医药,2024,64(2):18-21,4.
