上海针灸杂志2024，Vol.43Issue(1)：10-16,7.DOI:10.13460/j.issn.1005-0957.2024.01.0010
"调理脾胃"针法治疗2型糖尿病皮肤瘙痒症的疗效观察及对T细胞亚群的影响
Therapeutic observation of"Tiao Li Pi Wei"acupuncture for pruritus in type 2 diabetes and its effect on T cell subsets
摘要
Abstract
Objective To observe the clinical efficacy of"Tiao Li Pi Wei"(regulating the spleen and stomach)acupuncture in treating pruritus in type 2 diabetes and its effect on T cell subsets.Method Eighty patients with type 2 diabetes complicated by pruritus were randomized into an observation group(40 cases,including 1 dropout)and a control group(40 cases,including 1 dropout).In addition to routine Western medications,the control group received oral Levocetirizine hydrochloride tablets,and the observation group received"Tiao Li Pi Wei"acupuncture.Before and after the intervention,the visual analog scale(VAS)score for assessing itching,itching symptoms,skin lesion score,and the peripheral blood cell subset levels CD4﹢,CD8﹢,Th1 and Th2 were observed for the two groups.The clinical efficacy was also compared.Result The total effective rate in the observation group was higher than that in the control group(P＜0.05).After the treatment,the VAS itching score dropped in both groups(P＜0.05)and was lower in the observation group than in the control group(P＜0.05).The scores of the size,intensity,attack frequency,and duration of pruritus decreased after the intervention in both groups(P＜0.05)and were lower in the observation group than in the control group(P＜0.05).The scores of skin scales,dryness,scratch scars,papules,and lichenization dropped after the treatment in the two groups(P＜0.05)and were lower in the observation group than in the control group(P＜0.05).In both groups,the CD4﹢ level increased(P＜0.05),and the CD8﹢ level decreased(P＜0.05)after the treatment;the observation group had a higher CD4﹢ level(P＜0.05)and a lower CD8﹢ level(P＜0.05)compared with the control group.After the intervention,the Th1 level dropped(P＜0.05),and the Th2 level increased(P＜0.05)in both groups;the observation group had a lower Th1 level(P＜0.05)and a higher Th2 level(P＜0.05)compared with the control group.Conclusion In addition to routine Western medications,"Tiao Li Pi Wei"needling method can reduce the clinical symptoms of pruritus in type 2 diabetes patients.The mechanism may be associated with the regulation of serum levels CD4﹢,CD8﹢,Th1 and Th2.关键词
针刺疗法/糖尿病/瘙痒症/T细胞亚群Key words
Acupuncture therapy/Diabetes mellitus/Pruritus/T cell subsets分类
医药卫生引用本文复制引用
解衍龙.."调理脾胃"针法治疗2型糖尿病皮肤瘙痒症的疗效观察及对T细胞亚群的影响[J].上海针灸杂志,2024,43(1):10-16,7.基金项目
天津市中医药管理局中医中西医结合课题重点项目(2019027) （2019027）
