上海针灸杂志2024，Vol.43Issue(1)：17-23,7.DOI:10.13460/j.issn.1005-0957.2024.01.0017
艾灸联合保真汤加减治疗糖尿病肾病的疗效观察及对CT灌注参数、Rho/ROCK信号通路蛋白的影响
Therapeutic observation of moxibustion plus modified Bao Zhen Tang for diabetic nephropathy and its effects on CT perfusion parameters and Pho/ROCK signaling pathway proteins
摘要
Abstract
Objective To observe the clinical efficacy of moxibustion plus modified Bao Zhen Tang in treating diabetic nephropathy due to dual deficiency of Qi and Yin and its effects on CT perfusion parameters and Pho/ROCK signaling pathway proteins.Method A total of 146 patients with diabetic nephropathy due to dual deficiency of Qi and Yin were randomly allocated to an observation group(74 cases)and a control group(72 cases).In addition to symptomatic treatment,the control group was given Irbesartan tablets,and the observation group received moxibustion combined with modified Bao Zhen Tang.The following items were observed for the two groups:the primary symptom score of traditional Chinese medicine(TCM),CT perfusion parameters[blood urea nitrogen(BUN),serum creatinine(SCr),urinary albumin excretion rate(UAER),and 24-hour urinary protein quantification(24 h Upro)],renal blood flow indicators[end-diastolic velocity(EDV),peak-systolic velocity(PSV),pulsatility index(PI),resistive index(RI)],serum inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6),and C-reactive protein(CRP)],and Rho//ROCK signaling pathway protein levels[Ras homolog gene family member A(RhoA),Rho-associated coiled-coil containing protein kinase Ⅰ(ROCKI),α-smooth muscle actin(α-SMA),and E-cadherin(E-Cad)].The clinical efficacy and adverse reactions were compared between the two groups.Result The total effective rate was 97.3%(72/74)in the observation group,significantly higher than 81.9%(59/72)in the control group(P＜0.05).After the intervention,the TCM primary symptom score dropped in the observation group and was lower than that in the control group(P＜0.05).The CT perfusion parameters decreased in both groups after the treatment(P＜0.05)and were lower in the observation group than in the control group(P＜0.05).After the treatment,the PSV and EDV accelerated in the observation group and were higher than those in the control group(P＜0.05);the RI and PI dropped in the observation group and were lower than those in the control group(P＜0.05).The serum inflammatory factor levels dropped after the treatment in the observation group and were lower than those in the control group(P＜0.05).The RhoA,ROCKI,and α-SMA protein levels decreased after the treatment in the observation group and were lower than those in the control group(P＜0.05),and the E-Cad protein level increased in the observation group and was higher than that in the control group(P＜0.05).The adverse reaction rate was 1.4%(1/74)in the observation group,lower than 19.4%(14/72)in the control group(P＜0.05).Conclusion In addition to symptomatic treatment,moxibustion plus modified Bao Zhen Tang can enhance the efficacy in treating patients with diabetic nephropathy due to dual deficiency of Qi and Yin.The mechanism may be related to improving CT perfusion parameters and regulating serum Rho/ROCK signaling pathway proteins.关键词
灸法/糖尿病并发症/糖尿病肾病/气阴两虚/Rho/ROCK信号通路蛋白Key words
Moxibustion/Diabetes complications/Diabetic nephropathies/Dual deficiency of Qi and Yin/Rho/ROCK signaling pathway proteins分类
医药卫生引用本文复制引用
赵小艳,王俊杰..艾灸联合保真汤加减治疗糖尿病肾病的疗效观察及对CT灌注参数、Rho/ROCK信号通路蛋白的影响[J].上海针灸杂志,2024,43(1):17-23,7.基金项目
河南省中医药科学研究专项课题(2022ZY1071) （2022ZY1071）
