上海针灸杂志2024，Vol.43Issue(1)：24-30,7.DOI:10.13460/j.issn.1005-0957.2024.01.0024
针药并用治疗气阴两虚兼瘀型糖尿病性勃起功能障碍的疗效观察及对血管内皮功能及相关生长因子的影响
Therapeutic observation of acupuncture combined with medication for diabetic erectile dysfunction due to dual deficiency of Qi and Yin complicated by stasis and its effects on vascular endothelial function and related growth factors
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture plus Yi Qi Yang Yin Huo Xue Fang in treating diabetic erectile dysfunction(DED)due to dual deficiency of Qi and Yin complicated by stasis and the effects on vascular endothelial function and related growth factors.Method Ninety patients with DED due to dual deficiency of Qi and Yin complicated by stasis were randomized into a treatment group and a control group,with 45 cases in each group.The control group received oral Tadalafil tablets,and the treatment group additionally received acupuncture plus Yi Qi Yang Yin Huo Xue Fang.Changes in the following items were compared:the international index of erectile function-5(IIEF-5)score,the symptom score of traditional Chinese medicine(TCM),and serum contents of endothelin-1(ET-1),angiotensin Ⅱ(Ang-Ⅱ),nitric oxide(NO),vasoactive intestinal peptide(VIP),vascular endothelial growth factor(VEGF),transforming growth factor-β(TGF-β),fibroblast growth factor 21(FGF-21),and insulin-like growth factor 1(IGF-1).The clinical efficacy was also compared between the two groups.Result After the treatment,the IIEF-5 score increased in both groups(P<0.05),the scores of erectile weakness,soreness in the lower back and knees,and stinging pain in the genitals,and the TCM symptom general score dropped in the control group(P<0.05),the TCM symptom component and total scores dropped in the treatment group(P<0.05);the IIEF-5 score was higher in the treatment group than in the control group(P<0.05),and the TCM symptom component and total scores were lower in the treatment group than in the control group(P<0.05).After the intervention,the serum ET-1 and AngⅡ contents dropped,and the NO and VIP contents increased in both groups(P<0.05);the serum ET-1 and AngⅡ contents were lower in the treatment group than in the control group,and the NO and VIP contents were higher in the treatment group(P<0.05).After the treatment,the serum VEGF and IGF-1 contents increased,and the TGF-β and FGF-21 contents dropped in the two groups(P<0.05);the serum VEGF and IGF-1 contents in the treatment group were higher than those in the control group,and the TGF-β and FGF-21 contents were lower in the treatment group(P<0.05).The total effective rate was 90.7％in the treatment group,higher than 73.8％in the control group(P<0.05).Conclusion Based on the Western pharmaceutical treatment,acupuncture plus Yi Qi Yang Yin Huo Xue Fang can improve clinical symptoms and enhance efficacy in treating patients with DED due to dual deficiency of Qi and Yin complicated by stasis.This may be associated with improving vascular endothelial function and regulating pertinent growth factors.关键词
针刺疗法/针药并用/糖尿病/勃起功能障碍/阳萎/气阴两虚/血管内皮功能/生长因子Key words
Acupuncture therapy/Acupuncture medication combined/Diabetes mellitus/Erectile dysfunction/Impotence/Dual deficiency of Qi and Yin/Vascular endothelial function/Growth factors分类
医药卫生引用本文复制引用
李振,李向团,王昊,刘媛,荀艳平..针药并用治疗气阴两虚兼瘀型糖尿病性勃起功能障碍的疗效观察及对血管内皮功能及相关生长因子的影响[J].上海针灸杂志,2024,43(1):24-30,7.基金项目
河北省中医药管理局科研计划项目(2019215) （2019215）
