上海针灸杂志2024，Vol.43Issue(1)：40-46,7.DOI:10.13460/j.issn.1005-0957.2024.01.0040
穴位埋线治疗便秘型肠易激综合征的疗效观察及对血清SP含量的影响
Observation of the therapeutic effect of catgut-embedding therapy in the treatment of constipation-predominant irritable bowel syndrome and its influence on serum SP content
摘要
Abstract
Objective To observe the clinical efficacy of acupoint catgut embedding in the treatment of constiption-predominant irritable bowel syndrome(IBS-C)and its effect on serum substance P(SP)content.Method Forty-three IBS-C patients were randomly divided into an observation group(22 cases)and a control group(21 cases).The observation group was treated with catgut-embedding therapy,and the control group was treated with Mosapride citrate dispersible tablets.IBS symptom severity scale(IBS-SSS)scores,irritable bowel syndrome quality of life(IBS-QOL)scores and self-rating anxiety scale(SAS)scores were observed before and after treatment and at follow-up,and serum SP levels were observed before and after treatment.Result Each IBS-SSS scores and total IBS-SSS scores after treatment and at follow-up were lower than those before treatment in the observation group(P＜0.05),and each IBS-SSS scores and total IBS-SSS scores at follow-up were higher than those after treatment(P＜0.05).Each item scores and total scores of IBS-SSS in the control group after treatment were lower than those before treatment(P＜0.05),and each item scores and total scores of IBS-SSS at follow-up were higher than those after treatment(P＜0.05).The abdominal pain and discomfort scores of the observation group were lower than those of the control group after treatment and at follow-up(P＜0.05).The total IBS-QOL scores of the two groups after treatment and at follow-up were higher than those before treatment,and the IBS-QOL scores of the two groups at follow-up were lower than those after treatment,and the differences were statistically significant(P＜0.05).After treatment and at follow-up,the IBS-QOL scores of the observation group were higher than those of the control group(P＜0.05).The SAS scores of the observation group after treatment and at follow-up were decreased(P＜0.05),and the SAS scores at follow-up were higher than that after treatment(P＜0.05).In the control group,the SAS scores after treatment were lower than that before treatment(P＜0.05),and the SAS scores at follow-up were higher than that after treatment(P＜0.05).The SAS scores of the observation group were lower than those of the control group after treatment and at follow-up(P＜0.05).After treatment,the serum SP levels of the two groups were decreased(P＜0.05).The serum SP level of the observation group was lower than that of the control group(P＜0.05).The clinical efficacy of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Both catgut-embedding therapy and mosapride citrate dispersible tablets can relieve the clinical symptoms and improve the quality of life in patients with IBS-C,but the clinical effect of catgut-embedding therapy is more stable and lasting than Mosapride citrate dispersible tablets.The long-term effect of catgut-embedding therapy is better in improving abdominal pain and quality of life.The mechanism of catgut-embedding therapy in the treatment of IBS-C may be closely related to the down-regulation of serum SP content.关键词
埋线/肠易激综合征/便秘/P物质/肠易激综合征症状严重程度量表/肠易激综合征生活质量量表/焦虑自评量表Key words
Catgut-embedding therapy/Irritable bowel syndrome/Constipation/Substance P/Irritable bowel syndrome symptom severity scale/Irritable bowel syndrome quality of life scale/Self-rating anxiety scale分类
医药卫生引用本文复制引用
陈盼碧,侯天仙,陈艺,金灵敏,况莎莎,杨孝芳..穴位埋线治疗便秘型肠易激综合征的疗效观察及对血清SP含量的影响[J].上海针灸杂志,2024,43(1):40-46,7.基金项目
贵州省研究生教育创新计划项目[黔教合YJSCXJH(2018)075] （2018）
贵州中医药大学重大专项项目[黔科合平台人才(2017)5735号-34] （2017）
