世界中医药2023，Vol.18Issue(22)：3202-3206,5.DOI:10.3969/j.issn.1673-7202.2023.22.007
乳核散结片抗炎镇痛的药理实验研究
Pharmacological Study of Ruhe Sanjie Tablet for Anti-inflammation and Analgesia
摘要
Abstract
Objective:To investigate the anti-inflammatory and analgesic effects of Ruhe Sanjie Tablet.Methods:Cotton pellet-in-duced granuloma formation of Sprague Dawley(SD)rats and the increase in capillary permeability of mice induced by xylene were used to observe the anti-inflammatory effect of Ruhe Sanjie Tablet.The acetic acid writhing experiment in mice was established to observe the analgesic effect of the prescription.Results:The low-,medium-and high-dose Ruhe Sanjie Tablet inhibited the prolifera-tion of rat granulation tissue,and there were differences compared with the blank control group(all P＜0.05).The inhibition rates of the three doses were 30.0％,47.4％and 53.6％,respectively,showing a dose-effect relationship.Ruhe Sanjie Tablet at low,medium and high doses reduced the capillary permeability of mice,and the optical density(OD)was lower than that in the blank control group(all P＜0.001).The inhibition rates of capillary permeability were 47.6％,55.0％and 65.2％,respectively,with a dose-effect relationship.Ruhe Sanjie Tablet at each dose lowered the number of writhing induced by acetic acid in mice(P＜0.001),and the analgesic inhibition rates at low,medium and high dose were 34.2％,42.0％and 51.5％,respectively,presenting a dose-effect relationship.Conclusion:Pharmacological studies of Ruhe Sanjie Tablet indicates that it has anti-inflammatory and analgesic effects.关键词
乳核散结片/抗炎/镇痛/疗效/药理实验/毛细血管通透性/结缔组织增生/乳癖消Key words
Ruhe Sanjie Tablet/Anti-inflammation/Analgesia/Curative effect/Pharmacological study/Capillary permeability/Connective tissue hyperplasia/Rupixiao分类
医药卫生引用本文复制引用
黄秋凌,郑明翠,宁娜..乳核散结片抗炎镇痛的药理实验研究[J].世界中医药,2023,18(22):3202-3206,5.基金项目
广东省重点领域研发计划项目(2020B1111110004) （2020B1111110004）
