塑料科技2023，Vol.51Issue(12)：32-37,6.DOI:10.15925/j.cnki.issn1005-3360.2023.12.007
3D打印聚(3-羟基丁酸酯-co-4-羟基丁酸酯)/掺锶羟基磷灰石人工骨支架的制备及性能评价
Preparation and Performance Evaluation of 3D Printed Poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/Strontium-Doped Hydroxyapatite Artificial Bone Scaffold
摘要
Abstract
To promote the rapid repair of bone defects,poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/strontium-doped hydroxyapatite(P34HB/SrHA)artificial bone repair scaffolds with a porous structure and different strontium-doped hydroxyapatite(SrHA)content were fabricated by 3D printing technology.The effects of SrHA content on the rheological properties,in vitro degradation properties and osteogenic activity of the composite scaffolds were studied.The results show that with SrHA content ranging from 0 to 20%,the apparent viscosity of P34HB/SrHA composites gradually decreases with increasing SrHA content,and SrHA significantly improves the printability of P34HB.3D printed P34HB/SrHA composite scaffolds exhibit a regular appearance and well-organized internal pore structure,with SrHA evenly distributed in the P34HB matrix.When the SrHA content is 20%,the compressive strength of the P34HB/SrHA composite scaffold is increased by 83.1%compared to the P34HB scaffold,indicating an enhancement in mechanical properties.The degradation of P34HB/SrHA composite scaffolds gradually occurrs over time,and the degradation rate is proportional to the SrHA content.Compared to the P34HB scaffold,the pH value of P34HB/SrHA composite scaffolds remains stable at 7.4±0.1,and SrHA plays a role in maintaining pH stability during degradation.P34HB/SrHA can promote cell proliferation and differentiation,and has good osteogenic induction activity.关键词
聚(3-羟基丁酸酯-co-4-羟基丁酸酯)/掺锶羟基磷灰石/3D打印/人工骨/骨修复Key words
P34HB/SrHA/3D print/Artificial bone/Bone repair分类
化学化工引用本文复制引用
王娜,于翔,武飞龙,张锦晓..3D打印聚(3-羟基丁酸酯-co-4-羟基丁酸酯)/掺锶羟基磷灰石人工骨支架的制备及性能评价[J].塑料科技,2023,51(12):32-37,6.基金项目
河南省高等学校重点科研项目计划(21A430008) （21A430008）
河南工程学院博士基金项目(2020007) （2020007）
