生命科学研究2023，Vol.27Issue(6)：551-558,8.DOI:10.16605/j.cnki.1007-7847.2022.11.0223
帕金森病与肠道微生物群相关性的研究进展
Research Advances in the Correlation Between Parkinson's Disease and Intestinal Microbiota
摘要
Abstract
Parkinson's disease(PD)is a serious threat to the health of middle-aged and elderly people.The etiology of the disease remains unclear.Recent studies have found that the occurrence of PD is closely related to the intestinal microbiome,which is involved in the process of PD by affecting the intestinal barrier permea-bility,inflammation and oxidative stress levels and the release of neurotransmitters through the microbe-gut-brain axis.Dietary intervention,supplementation with suitable probiotics and fecal microbiota transplantation(FMT)can effectively alleviate or improve the symptoms of PD,and may be useful to treat the disease.How-ever,due to the great heterogeneity of gut microbes,much work needs to be done to reveal the correlation between PD and intestinal microbiome.关键词
帕金森病(PD)/肠道微生物群/微生物-肠-脑轴Key words
Parkinson's disease(PD)/intestinal microbiota/microbe-gut-brain axis分类
生物科学引用本文复制引用
许龙,雷立芳,谭志霞,廖旻晶,蔡秀怡,刘年猛,叶湘漓..帕金森病与肠道微生物群相关性的研究进展[J].生命科学研究,2023,27(6):551-558,8.基金项目
国家自然科学基金面上项目(81971086) （81971086）
湖南省发育生物学与生物育种优势特色学科群交叉研究项目(2022XKQ0205) （2022XKQ0205）
湖南省卫生健康委员会重点项目(202201065690) （202201065690）
湖南省普通高等学校教学改革研究项目(HNJG-2020-1286) （HNJG-2020-1286）
长沙市卫生健康委员会科研项目(KJ-B2023101) （KJ-B2023101）
湖南师范大学基层教学组织建设项目(202101003015) （202101003015）
