含栀子治疗抑郁方剂的疗效及安全性Meta分析OACSTPCD

The clinical trial data of prescriptions containing Gardeniae Fructus were collected from Chinese literature regarding the treatment of depression.Upon the exclusion of duplicate documents from electronic database,we utilized Revman 5.3 software to evaluate the quality of research papers,then extracted the corresponding data for Meta-analysis,aiming to assess the clinical safety and efficacy of antidepressant prescriptions containing Gardeniae Fructus.Three keywords including"Gardeniae Fructus","Chinese medicine",and"depression"appeared in 38 articles from the total of 3 960 publications,and the Meta-analysis demonstrated:a)the prescriptions,either containing Gardeniae Fructus alone[RR=1.15,95％CI(1.10,1.21);P＜0.000 01]or with combination with antidepressants[RR=1.23,95％CI(1.18,1.28);P＜0.000 01]showed higher effective rate than antidepressants with regard to clinical efficiency.b)In terms of HAMD scaling rate,the prescriptions,either containing Gardeniae Fructus alone[MD=-1.79,95％CI(-2.84,-0.74);P=0.000 8]or in combination with antidepressants[MD=-5.14,95％CI(-6.57,-3.70);P＜0.000 01]could reduce HAMD more significantly than antidepressants alone.c)Regarding adverse effects,the prescriptions,either containing Gardeniae Fructus alone[RR=0.12,95％CI(0.07,0.23);P＜0.000 01]or with the combination with antidepressants[RR=0.47,95％CI(0.32,0.69);P=0.000 1],proved to be safer than antidepressants.In conclusion,the prescriptions containing Gardeniae Fructus would offer a better option for patients with depressive disorder.