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具有Markov切换的随机基因表达调控模型

闫博伦 唐若诗 邱志鹏

山西大学学报(自然科学版)2024,Vol.47Issue(1):122-133,12.
山西大学学报(自然科学版)2024,Vol.47Issue(1):122-133,12.DOI:10.13451/j.sxu.ns.2023080

具有Markov切换的随机基因表达调控模型

A Stochastic Gene Expression Regulation Model with Markov Switching

闫博伦 1唐若诗 1邱志鹏2

作者信息

  • 1. 南京理工大学 数学与统计学院,江苏 南京 210094
  • 2. 南京理工大学 基础前沿交叉中心,江苏 江阴 214443
  • 折叠

摘要

Abstract

Both white noise and Markov switching are introduced to study the dynamics of gene cooperative expression system.The random attraction set of the model is constructed based on the random comparison principle.The conclusion shows that the solution of the system is uniformly bounded under the influence of environmental noise.It is proved that the model has a unique ergodic sta-tionary distribution and the solution of the system is ergodic by constructing a suitable Lyapunov function.Some numerical simula-tions are carried out to support the results,and the numerical results show that the bistable phenomenon exists in the model studied,which is of great significance for the research of cell differentiation and other biological fields.

关键词

布朗运动/保序系统/Markov链/随机吸引集/平稳分布

Key words

Brownian motion/order-preserving system/Markov chain/random attracting set/stationary distribution

分类

数理科学

引用本文复制引用

闫博伦,唐若诗,邱志鹏..具有Markov切换的随机基因表达调控模型[J].山西大学学报(自然科学版),2024,47(1):122-133,12.

基金项目

国家自然科学基金(12071217) (12071217)

山西大学学报(自然科学版)

OA北大核心CSTPCD

0253-2395

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