现代检验医学杂志2024，Vol.39Issue(1)：152-157,6.DOI:10.3969/j.issn.1671-7414.2024.01.028
2012～2021年四川成都某医院临床患者血型意外抗体筛查结果与疾病类型分析
Analysis of Blood Type Unexpected Antibody Screening Results and Disease Types of Clinical Patients from A Hospital in Chengdu,Sichuan Province from 2012 to 2021
摘要
Abstract
Objective To analyze blood type unexpected antibody and disease characteristics of inpatients in a hospital,and provide a reference for optimizing precise transfusion schemes and improving clinical transfusion safety.Methods The data of unexpected antibody screening and identification in the General Hospital of Western Theater Command from January 2012 to December 2021 were collected,while information on these patient age,gender,blood transfusion history,pregnancy history and disease diagnosis were also collected.The positive rate,composition ratio and disease characteristics of unexpected antibodies were analyzed.Results The positive rate of unexpected antibody screening was 0.55%(1 736/315 456),in which females were higher than males(0.69%vs 0.44%,χ2=90.107,P＜0.05),patients with a history of blood transfusion or(and)pregnancy were higher than those without a history of blood transfusion or(and)pregnancy(75.69%vs 22.81%,χ2=971.098,P＜0.05),and patients aged 40～80 accounted for 72.93%(1 266/1 736).Patients diseases with unexpected antibody positive accounted for 80.41%(1 396/1 736),mainly including digestive system diseases,immune diseases of blood and hematopoietic organs,tumors,urogenital system diseases,circulatory system diseases,musculoskeletal system and connective tissue diseases.Moreover,91.88%(1 595/1 736)of the patients with anti-screening positive underwent antibody identification,in which the majority of unexpected antibodies were Rh blood group system[41.57%(663/1 595)],Lewis blood group system[11.22%(179/1 595)],and MNS blood group system[6.90%(110/1 595)].Antibody specificity was mainly characterized by anti-E[32.41%(517/1 595)],anti-Lea[10.47%(167/1 595)],and anti-M 6.08%(97/1 595).Other antibodies[35.8%(571/1 595)]were mainly no-detected specific antibodies.Conclusion The screening results of blood type unexpected antibodies and disease type analysis are of great significance for transfusion safety.Blood transfusion department should carry out precise blood transfusion matching with multiple antigens(RhCcDEe,Lea,M)for long-term transfusion patients,women,and patients with pregnancy or blood transfusion history,so as to reduce the incidence of unexpected antibodies and improve transfusion safety.关键词
血型/意外抗体/抗体筛查/抗体鉴定/输血Key words
blood group/unexpected antibody/antibody screening/antibody identification/transfusion分类
医药卫生引用本文复制引用
杨俊龙,张利,肖洁,黎欢,杨鑫,彭涛..2012～2021年四川成都某医院临床患者血型意外抗体筛查结果与疾病类型分析[J].现代检验医学杂志,2024,39(1):152-157,6.基金项目
四川省科技计划项目(NO.2019YFS0273):基于不同医疗救治能力的精准输血多中心研究 （NO.2019YFS0273）
成都医学院校基金2020年自然科学重点项目(NO.CYZZD20-05):四川地区汉族孕妇发生RhE抗原同种免疫风险与HLA-ORB1基因多态性的相关性研究. （NO.CYZZD20-05）
