现代检验医学杂志2024，Vol.39Issue(1)：186-191,6.DOI:10.3969/j.issn.1671-7414.2024.01.035
内源性因素对抗体夹心免疫法检测血清心肌肌钙蛋白I的干扰及解决方案研究进展
Research Progress on Interference of Endogenous Factors in Detection of Serum Cardiac Troponin I by Sandwich Antibody Immunoassay and Its Solutions
摘要
Abstract
Cardial troponin I(cTnI)is the preferred serological marker for the diagnosis of myocardial injury.cTnI detection is based on antibody sandwich immunoassay.The epitopes of cTnI antigen targeted by detecting and capturing antibodies in different detection reagents are inconsistent,which easily leads to the heterogeneity of cTnI detection results.Endogenous interfering factors such as cTnI autoantibody,heterophile antibody,rheumatoid factor,ect,which can seriously interfere with the results of cTnI detection,and affecting the clinical diagnosis,treatment and prognosis of myocardial injury diseases.In this paper,the research progress of antibody sandwich immunoassay for cTnI and interference of endogenous factors on cTnI detection and solutions are reviewed to provide theoretical basis for differential diagnosis of abnormal cTnI detection results in clinical practice.关键词
心肌肌钙蛋白I/抗体/夹心免疫/干扰/内源性因素Key words
cardiac troponin I/antibodies/sandwich immunoassay/interference/endogenous factor分类
医药卫生引用本文复制引用
何成山,刘洋,徐正,蒋秀娣,陆志成..内源性因素对抗体夹心免疫法检测血清心肌肌钙蛋白I的干扰及解决方案研究进展[J].现代检验医学杂志,2024,39(1):186-191,6.基金项目
上海市卫生健康委员会科研面上项目(202040165):循环心肌肌钙蛋白I自身抗体对心肌肌钙蛋白I检测的影响及相关机制 （202040165）
浦东新区卫生健康委员会公共卫生学科:预防医学与检验学(PWGw2020-02). （PWGw2020-02）
