实用医学杂志2024，Vol.40Issue(1)：72-78,7.DOI:10.3969/j.issn.1006-5725.2024.01.013
C反应蛋白/白蛋白比值与维持性血液透析患者心血管事件风险的关系
The association between C-reactive protein/albumin ratio and the risk of cardiovascular events in mainte-nance hemodialysis patients
摘要
Abstract
Objective To explore the association between C-reactive protein/albumin ratio(CAR)and the risk of cardiovascular events in maintenance hemodialysis(MHD)patients.Methods This study enrolled MHD patients who were treated in the blood purification center of the Second Affiliated Hospital of Guangzhou Medical University between August 2016 to December 2019,and the follow-up deadline was March 31,2021.Collected the clinical data of patients who conform to the inclusion criteria,including demographic,complications,primary basic disease,biochemical indicators of the patients who underwent 3 months regular dialysis treatment and the occurrence of cardiovascular events during the follow-up period.The Kaplan-Meier method was used to estimate the probability of cardiovascular incidents in MHD patients.The Cox proportional hazards model based on generalized propensity score weighting(GPSW)was used to estimate the relationship between CAR and cardiovas-cular events in MHD patients.Results A total of 170 eligible objects were included in this study,64 patients with cardiovascular events(37.6%).The Cox proportional hazards model which based on GPSW(HRCAR = 2.087,95%CI:1.085～4.015,P = 0.028),indicated that the hazard ratio of cardiovascular events was 2.087 when the CAR each additional a unit in MHD patients.Conclusion CAR and the risk of cardiovascular events in MHD patients have a significant positive correlation,which can help clinical workers recognize the MHD patients who have high risk of cardiovascular events and intervene in time.关键词
C反应蛋白/白蛋白比值/维持性血液透析/心血管事件/广义倾向性得分/逆概率加权Key words
C-reactive protein to albumin ratio/maintenance hemodialysis/cardiovascular events/generalized propensity score/inverse probability weighting分类
医药卫生引用本文复制引用
母元梅,赵佳圆,张莹..C反应蛋白/白蛋白比值与维持性血液透析患者心血管事件风险的关系[J].实用医学杂志,2024,40(1):72-78,7.基金项目
广东省医学科研基金项目(编号:A2021398) （编号:A2021398）
广州医科大学第二临床学院大学生科技创新项目(编号:R2022A035) （编号:R2022A035）
