土壤2023，Vol.55Issue(6)：1161-1169,9.DOI:10.13758/j.cnki.tr.2023.06.001
土壤多环芳烃生物可给性测定的体外胃肠模拟法研究进展
Advances of in vitro Gastrointestinal Simulation Methods for Determining Bioaccessibility of Polycyclic Aromatic Hydrocarbons(PAHs)in Soil
摘要
Abstract
Oral ingestion is an important route of human exposed to soil polycyclic aromatic hydrocarbons(PAHs).Effective assessment of the bioaccessibility of PAHs is an important component of a comprehensive assessment of the human health risk of PAHs in soil.However,there are many in vitro gastrointestinal simulation methods to evaluate the bioaccessibility of soil PAHs,and there is still no uniform standard in China as well as abroad.The development of human health risk assessment of soil PAHs has been hampered by the large variation in the results of different in vitro simulation methods.Thus,this paper reviewed various in vitro gastrointestinal simulation methods and the related advances for PAHs bioavailability determination,and suggested that future research on the construction of standard methods for PAHs bioaccessibility determination in soils should be based on three aspects:physiological conditions,selection of adsorbent materials,and validation of in vivo models.关键词
有机污染物/PAHs/体外胃肠模拟/生物有效性/人体健康风险评估Key words
Organic pollutants/PAHs/in vitro gastrointestinal simulation/Bioavailability/Human health risk assessment分类
资源环境引用本文复制引用
马俊超,高彦征,秦超..土壤多环芳烃生物可给性测定的体外胃肠模拟法研究进展[J].土壤,2023,55(6):1161-1169,9.基金项目
国家自然科学基金项目(42107221)和国家杰出青年科学基金项目(41925029)资助. （42107221）
