武警医学2024，Vol.35Issue(1)：1-5,5.
红景天苷对血管生成及骨血管偶联的影响
Effect of salidroside on angiogenesis and bone vessel coupling
祁琳 1韩鑫羽 2祁璐 3王越 4张磊1
作者信息
- 1. 300162 天津,武警特色医学中心:药剂科
- 2. 300162 天津,武警特色医学中心:耳鼻喉科
- 3. 300308,天津医科大学总医院空港医院急诊科
- 4. 301617,天津中医药大学中西医结合学院
- 折叠
摘要
Abstract
Objective To study the effect of salidroside(SAL)on angiogenesis and bone vessel coupling.Methods MTS method was used to investigate the effect of osteoblast-conditioned medium on the proliferation activity of vascular endothelial cells.Tr-answell cell migration assay was used to investigate the effect of osteoblast-conditioned medium on the migration of vascular endothelial cells.Matrigel lumen formation experiment was used to investigate the effect of osteoblast-conditioned medium on lumen formation length.Fetal metatarsal angiogenesis assay was used to evaluate the effect of SAL on the sprouting area of endothelial cells.Results Compared with the conditioned culture medium group,the cell activity of the conditioned culture medium group after SAL treatment significantly increased,and the differences were statistically significant(P<0.01).The number of vascular endothelial cell migration and the length of HUVEC lumen formation in SAL group significantly increased compared with that in conditioned culture me-dium group,and the difference was statistically significant(P<0.01).The area of endothelial cell budding in SAl and vascular endo-thelial growth factor(VEGF)treatment groups was significantly larger than that in the control group,with statistical significance(P<0.01),and the above effects could be blocked by the anti-VEGF antibody Avastin.Conclusions SAL is a good angiogenic drug mon-omer,and can promote bone vascular coupling by up-regulating the expression of VEGF.关键词
红景天苷/血管内皮细胞/血管内皮生长因子/血管生成/骨血管偶联Key words
salidroside/vascular endothelial cell/vascular endothelial growth factor/angiogenesis/bone vessel coupling分类
医药卫生引用本文复制引用
祁琳,韩鑫羽,祁璐,王越,张磊..红景天苷对血管生成及骨血管偶联的影响[J].武警医学,2024,35(1):1-5,5.
