中国组织工程研究2024，Vol.28Issue(22)：3597-3602,6.DOI:10.12307/2024.477
聚合物基抗生素缓释载体治疗慢性骨髓炎
Polymer-based antibiotic sustained-release carrier in treatment of chronic osteomyelitis
摘要
Abstract
BACKGROUND:In the treatment strategy of chronic osteomyelitis,the local antibiotic slow-release system has attracted much attention in the clinic due to the long-term release of effective concentrations of antibiotics to control the infection,and at the same time,the ability to repair bone defects caused by debridement. OBJECTIVE:To summarize the research status of antibiotic sustained-release carriers prepared from biodegradable polymer-based materials for the treatment of osteomyelitis,and analyze the limitations and challenges. METHODS:Chinese and English key words were"polymer,composite material,osteomyelitis,infectious bone defect,drug delivery systems,antibiotic sustained-release system,3D printing".Relevant articles were searched in PubMed,Web of Science,CNKI,and WanFang databases from January 2015 to August 2023.4 351 articles were obtained in the initial examination,and 87 articles were analyzed after screening. RESULTS AND CONCLUSION:Polymer-based materials have been widely studied in the preparation of antibiotic sustained-release carriers due to their good biocompatibility,biodegradability,thermal stability,and easy processing.However,the antibiotic slow-release carrier composed of a single polymer material cannot meet the standard of infectious bone defect repair materials due to the lack of biomechanical properties.The organic-inorganic composite material carrier,which simulates the formation of natural bone tissue structure,is expected to meet this standard.3D printing technology can precisely control the size,geometry,and spatial distribution of the interconnecting pores of the carrier,and can load the effective concentration of antibiotics to achieve controlled release.The polymer material is the most suitable for 3D printing because of its good thermal stability and plasticity.Therefore,the author believes that on the basis of new biodegradable organic-inorganic composite materials and combined with 3D printing technology,the material-structure-function integrated composite antibiotic slow-release carrier to simulate the extracellular matrix microenvironment is expected to become a novel research direction in the treatment of chronic osteomyelitis.关键词
聚合物/复合材料/骨髓炎/感染性骨缺损/药物递送系统/抗生素缓释系统/3D打印Key words
polymer/composite material/osteomyelitis/infectious bone defect/drug delivery system/antibiotic sustained-release system/3D printing分类
医药卫生引用本文复制引用
伊力哈木•麦麦提阿卜杜拉,黄晓夏,李璐遥,滕勇..聚合物基抗生素缓释载体治疗慢性骨髓炎[J].中国组织工程研究,2024,28(22):3597-3602,6.基金项目
新疆维吾尔自治区自然科学基金资助项目(2023D01C93),项目负责人:滕勇 （2023D01C93）
新疆维吾尔自治区区域协同创新专项(科技援疆)计划(2019E0277),项目负责人:滕勇 Natural Science Foundaton of Xinjiang Uygur Autonomous Region,No.2023D01C93(to TY) （科技援疆）
Xinjiang Uygur Autonomous Region Regional Collaborative Innovation Project(Technology Aid to Xinjiang),No.2019E0277(to TY) （Technology Aid to Xinjiang）
