中国组织工程研究2024，Vol.28Issue(27)：4288-4292,5.DOI:10.12307/2024.572
孟德尔随机化分析血液代谢物与肌少症相关特征的因果关系
Causal relationship between blood metabolites and sarcopenia-related traits:a Mendelian randomization study
陈天鑫 1董婷婷 1李妍 1张晟 1张磊1
作者信息
- 1. 中国中医科学院望京医院骨关节四科,北京市 100102
- 折叠
摘要
Abstract
BACKGROUND:Clinical evidences have suggested a correlation between metabolic factors and sarcopenia.Blood metabolites have been found as biological factors underlying the mechanisms of musculoskeletal disorders.However,the causal relationship between blood metabolites and sarcopenia is unclear.
OBJECTIVE:To explore the causal relationship between blood metabolites and sarcopenia-related traits through a two-sample Mendelian randomization analysis and to analyze their metabolic pathways.
METHODS:A dataset of 486 blood metabolites and sarcopenia-related traits was obtained from public databases.The inverse variance weighting,MR-Egger and weighted median methods were used to assess the causal relationship of blood metabolites with muscle mass and strength across genders.Sensitivity analyses,including heterogeneity and gene pleiotropy,were performed to explore the robustness of the results.Metabolic pathway analysis of potential causal relationships was performed using the Metaboanayst 5.0 tool.
RESULTS AND CONCLUSION:A total of 124 metabolites and sarcopenia-related traits were observed to have potential causal relationships(P<0.05).Mannose and 1-arachidonoylglycerophosphocholine were significantly causally associated with an increased muscle mass in males(P<1.03×10-4).Pentadecanoate and glycine were significantly causally associated with decreased muscle mass and muscle strength in females,respectively(P<1.03×10-4).Metabolic pathway analysis identified eight metabolic pathways associated with altered levels of muscle mass and muscle strength in sarcopenia,including the"glyoxylate and dicarboxylate metabolism"and"Glycine,serine and threonine metabolism."The identified metabolites are considered as useful circulating metabolic biomarkers for screening and prevention of sarcopenia in clinical practice,serving as candidate molecules for future mechanistic exploration and drug target selection.关键词
血液代谢物/肌少症/孟德尔随机化/代谢通路/因果关系Key words
blood metabolite/sarcopenia/Mendelian randomization/metabolic pathway/causal relationship分类
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陈天鑫,董婷婷,李妍,张晟,张磊..孟德尔随机化分析血液代谢物与肌少症相关特征的因果关系[J].中国组织工程研究,2024,28(27):4288-4292,5.
