VAV家族在膀胱尿路上皮癌中的表达及其与预后的关系OA

Objective To study the expression of VAV family(VAV1,VAV2,VAV3)in bladder urothelial carcinoma,and to analyze the relationship between VAV1,VAV2,VAV3 and prognosis of the pa-tients with bladder urothelial carcinoma.Methods The data of bladder urothelial carcinoma and normal blad-der urothelial tissue were downloaded by the TCGA database,which were extracted by R language for conduc-ting the analysis.The expression situation of each gene in urinary urothelial carcinoma and normal urinary urothelial tissue of bladder was obtained.The survival curve was drawn according to the patient's outcome and the expression level in bladder urothelial carcinoma was further conducted the immunohistochemistric verifica-tion.Results The expression levels of VAV1 had no significant difference between urothelial carcinoma and normal bladder urothelial tissue(P＞0.05).The expression levels of VAV2 and VAV3 in the bladder urothe-lial carcinoma tissue were higher than that in normal bladder urothelial tissues,the difference was statistically significant(P＜0.05),and had no significant correlation with the bladder differentiation degree(P＞0.05).The expression levels of VAV1 and VAV2 had no significant correlation with the survival time of the patients(P＞0.05).The higher the expression of VAV3,the shorter the survival time of the patients(P＜0.000 1).Conclusion VAV2 and VAV3 may be involved in the change progression of bladder urothelial carcinoma,and VAV3 may be related to the poor prognosis of the patients.