新发传染病电子杂志2023，Vol.8Issue(6)：58-62,5.DOI:10.19871/j.cnki.xfcrbzz.2023.06.011
2016-2021年唐山地区非结核分枝杆菌流行及耐药情况分析
Analysis of the prevalence and drug resistance of non tuberculosis mycobacterium in Tangshan from 2016 to 2021
摘要
Abstract
Objective To analyze the prevalence and drug resistance of non tuberculosis mycobacterium(NTM)in Tangshan area,and to provide a basis for the prevention and treatment of NTM disease.Method Through a retrospective study,the NTM isolation rate and drug sensitivity test results of Tangshan area from January 2016 to December 2021 were collected.The trend of NTM isolation rate and corresponding bacterial composition ratio were analyzed by trend testing.The difference in NTM drug resistance rate was compared through χ2 test.Result A total of NTM 390 strains were isolated from sputum samples of 2487 suspected tuberculosis patients,and the separation rate was 15.68%.The isolation rates of NTM each year were 13.89%,14.12%,14.36%,17.44%,15.69%,and 18.37%,respectively.The top three dominant strains in NTM were Mycobacterium intracellularis(62.31%),Mycobacterium kansas(18.72%),and Mycobacterium abscessus(9.49%).The order of resistance rate of single anti NTM drugs was imipenem and cilastatin(IC)(80.3%)＞doxycycline(DOX)(55.49%)＞minocycline(MNO)(43.35%)＞sulfamethazole(SMZ)(28.32%)＞cefoxitin(FOX)(24.86%)＞tobramycin(TOB)(17.92%)＞ethambutol(EMB)(14.45%)＞rifampin(RFP)(10.98%)＞azithromycin(AZM)(9.83%)＞gatifloxacin(GAT)(8.67%)＞rifabutin(RFb)(8.09%)＞linezolid(LZD)(7.51%)＞clarithromycin(CLA)(4.62%)= amikacin(AMK)(4.62%)＞moxifloxacin(MXF)(1.73%).The trend test results showed a statistically significant increase in the resistance rate to IC、DOX(χ2=23.204,4.349,P＜0.05).Conclusion Mycobacterium intracellularis,Mycobacterium Kansas,and Mycobacterium abscessus were the dominant NTM strains in Tangshan area.The resistance rates of some anti-NTM drugs are on the rise,and attention should be paid to the diagnosis and rational use of NTM infection in clinical diagnosis and treatment.关键词
分枝杆菌/非结核分枝杆菌/药物敏感试验/分离率/耐药率Key words
Mycobacteria/Non tuberculosis mycobacterium/Susceptibility assay/Isolation rate/Drug resistance rate分类
医药卫生引用本文复制引用
刘海涛,田杰,韩云艳,赵俊鹏..2016-2021年唐山地区非结核分枝杆菌流行及耐药情况分析[J].新发传染病电子杂志,2023,8(6):58-62,5.基金项目
河北省2022年度医学科学研究重点课题计划(20221806) （20221806）
