HMGB1在调节骨关节炎软骨细胞功能中的作用机制OACSTPCD
Research Progress on the Role of HMGB1 in Regulating the Function of Osteoarthritis Chondrocytes
骨关节炎(osteoarthritis,OA)是一种慢性退行性关节疾病,其主要特征是关节软骨破坏,导致患者身体疼痛和残疾,严重影响其生活质量.OA可由多种病因诱发,而关节软骨的病理改变被认为是OA发生的关键驱动因素之一.高迁移率族蛋白1(high mobility group box-1 protein,HMGB1)作为一种真核细胞内的非组蛋白,可参与调节软骨细胞炎症及凋亡过程,从而导致关节软骨受损,诱发OA.本文就HMGB1 在OA软骨细胞中的作用机制进行综述,以期为临床防治OA提供新思路.
Osteoarthritis(OA)is a chronic degenerative joint disease whose main characteristic is the destruction of articular cartilage,causing pain and disability in patients and seriously affecting their quality of life.OA can be induced by a variety of causes,and pathological changes in articular cartilage are considered to be one of the key driving factors for the occurrence of OA.High mobility group box-1 protein(HMGB1),as a non-histone protein in eukaryotic cells,can participate in regulating the inflammation and apoptosis process of OA chondrocytes,thus leading to the occurrence of OA.This article reviews the research on the mechanism of HMGB1 in OA chondrocytes,with a view to providing new ideas for the clinical prevention and treatment of OA.
齐鑫;马姣姣;齐伟;胡紫阳;刘建军;张晓刚;于海洋;陈欣;安文博;王志鹏;王多贤;罗鹏飞;陈一新
甘肃中医药大学, 兰州 730000甘肃中医药大学附属医院, 兰州 730000
临床医学
骨关节炎高迁移率族蛋白1软骨细胞信号通路
osteoarthritishigh mobility group box-1 proteinchondrocytessignal pathway
《协和医学杂志》 2024 (001)
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张晓刚全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75 号);2021 年卫生健康行业科研项目(GSWSKY-2021-069);甘肃中医药大学研究生创新基金 Zhang Xiaogang National Famous Traditional Chinese Medicine Expert Inheritance Studio Construction Project(National Traditional Chinese Medicine Human Education Letter[2022]No.75);2021 Health Industry Scientific research pro-ject(GSWSKY-2021-069);Gansu University of Traditional Chinese Medicine Graduate Student Innovation and Entre-preneurship Project
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