协和医学杂志2024，Vol.15Issue(1)：153-159,7.DOI:10.12290/xhyxzz.2023-0396
中性粒细胞胞外陷阱在慢性阻塞性肺疾病中的作用
Role of Neutrophil Extracellular Traps in Chronic Obstructive Pulmonary Disease
摘要
Abstract
Chronic obstructive pulmonary disease(COPD),a respiratory disease characterized by in-flammation due to neutrophil infiltration,has become the third leading cause of death worldwide.After the oc-currence of COPD,the persistent accumulation of neutrophils can promote the excessive formation of neutrophil extracellular traps(NETs),which plays an important role in local capture and clearance of pathogens,rapid control of infection,and immune regulation.This article mainly introduces the mechanism of COPD occurrence and NETs formation as well as the research progress of NETs in COPD,and summarizes the relevant drug tar-gets for COPD treatment based on NETs,aiming to provide a reference for further research.关键词
慢性阻塞性肺疾病/中性粒细胞胞外陷阱/靶向治疗/作用机制Key words
chronic obstructive pulmonary disease/neutrophil extracellular traps/targeted therapy/mechanism of action分类
医药卫生引用本文复制引用
许金回,岳红梅,刘苗苗,李雅亭,武兴东,朱浩斌..中性粒细胞胞外陷阱在慢性阻塞性肺疾病中的作用[J].协和医学杂志,2024,15(1):153-159,7.基金项目
Gansu Provincial Science and Technology Program(22ZD1FA001) 甘肃省科技计划(22ZD1FA001) （22ZD1FA001）
