乳腺癌共发甲状腺癌的危险因素及预后分析OACSTPCD

Objective To analyze the risk and prognostic factors for synchronous breast cancer(BC)and thyroid cancer(TC).Methods The Surveillance,Epidemiology,and End Results Program(SEER)2020 database was utilized to collect the information of patients with synchronous BC and TC(BC and TC group)and those with BC alone(BC group).Clinical data and survival were compared between two groups.Clinical data of patients with synchronous BC and TC(BC and TC group A)and those with BC alone(BC group B)admitted to a certain hospital were retrospectively analyzed.Clinical data and survival were also compared between two groups.Results ① Analysis of SEER database,482 patients in BC and TC group and 500 patients in BC group.Univariate analysis revealed that age at first diagnosis and progesterone receptor(PR)were the risk factors for synchronous BC and TC(both P＜0.05).Multivariate analysis found that age at first diagnosis(OR=1.800,95％CI:1.387-2.337,P＜0.001)and PR(OR=1.364,95％CI:1.023-1.818,P=0.034)were the independent risk factors for synchronous BC and TC.Excluding those with incomplete follow-up data,univariate analysis indicated that tumor diameter and PR were the prognostic factors for synchronous BC and TC(both P＜0.05);multivariate analysis revealed that tumor diameter was an independent prognostic factor for synchronous BC and TC(OR=4.328,95％CI:1.410-13.288,P=0.010).Univariate analysis found that age at first diagnosis and tumor diameter were the prognostic factors for BC alone(both P＜0.05);multivariate analysis identified that age at first diagnosis(OR=2.443,95％CI:1.014-5.889,P=0.047)and tumor diameter(OR=2.030,95％CI:1.039-3.969,P=0.038)were the independent prognostic factors for BC alone.(2)Analysis of inpatients,there were 40 patients each in BC and TC group A and BC group A.Univariate analysis indicated that menstrual status,PR,proliferation index Ki-67,and TT3 were the risk factors for synchronous BC and TC(all P＜0.05),multivariate analysis found that menstrual status(synchronous BC and TC versus BC alone,OR=0.175,95％CI:0.052-0.591,P=0.005),PR(OR=5.686,95％CI:1.677-19.282,P=0.005),Ki-67(OR=3.966,95％CI:1.133-13.875,P=0.031)were the independent risk factors for synchronous BC and TC.Eighty patients were subject to follow-up,6 patients died,27 survived,and 7 were lost to follow-up in BC and TC group A;2 patients died,29 survived,and 9 were lost to follow-up in BC group A.Cox regression analysis revealed no statistical significance in both groups.Conclusions Age at first diagnosis,menstrual status,PR,and Ki-67 are the risk factors for synchronous BC and TC.Tumor diameter is an independent prognostic factor for synchronous BC and TC.Age at first diagnosis and tumor diameter are the independent prognostic factors for BC alone.