疑难病杂志2024，Vol.23Issue(1)：41-45,5.DOI:10.3969/j.issn.1671-6450.2024.01.007
肺癌患者bFGF、miR-1233、D-二聚体及Fib水平变化与肺栓塞发生的关系
The relationship between changes in bFGF,miR-1233,D-dimer,and Fib levels and the occurrence of pulmonary embolism in lung cancer patients
摘要
Abstract
Objective To analyze the correlation between changes in levels of basic fibroblast growth factor(bF-GF),microribonucleic acid-1233(miR-1233),D-dimer(D-D),and fibrinogen(Fib)and the occurrence of pulmonary embolism in lung cancer patients.Methods One hundred and ten lung cancer patients with pulmonary embolism diagnosed in the Re-spiratory Department of North China University of Technology Affiliated Hospital from June 2018 to June 2021 were selected as the embolism group.In addition,110 lung cancer patients who were admitted to the hospital during the same period but did not have pulmonary embolism were selected as the non-embolism group.The serum bFGF,miR-1233,plasma D-D,Fib levels,coagulation function indicators,comorbidities,lung cancer pathology indicators,and other related data of the two groups of patients were compared at admission;The value of receiver operating characteristic curve(ROC)analysis of bFGF,miR-1233,D-D,and Fib in predicting the occurrence of pulmonary embolism in patients;Logistic regression model was used to analyze the relationship between bFGF,miR-1233,D-D,Fib and the occurrence of pulmonary embolism in lung cancer pa-tients.Results The levels of bFGF,miR-1233,D-D,and Fib in the embolization group were higher than those in the non-embolization group(t/P=4.749/<0.001,9.244/<0.001,16.846/<0.001,9.389/<0.001);The PT,APTT,and INR measurements of patients in the embolization group were lower than those in the non-embolization group(t/P=8.131/<0.001,7.875/<0.001,6.379/<0.001);The areas under the ROC curve(AUC)predicted by bFGF,miR-1233,D-D,and Fib for pulmonary em-bolism in lung cancer patients were 0.687,0.821,0.947,and 0.766,respectively,with D-D having the highest AUC(Z/P= 5.102/<0.001,4.910/<0.001,3.776/<0.001);Logistic regression model analysis showed that bFGF,miR-1233,D-D,and Fib were all elevated,Atrial fibrillation was an independent risk factor for pulmonary embolism in lung cancer patients[OR(95%CI)=1.486(1.059-2.086),1.672(1.128-2.479),2.018(1.246-3.268),1.912(1.066-3.428),2.164(1.298-3.609)],PT,APTT and INR were all elevated was an independent protective factors[OR(95%CI)=0.618(0.404-0.946),0.640(0.428-0.956),0.501(0.280-0.894)].Conclusion Elevated levels of serum bFGF,miR-1233,plasma D-D,and Fib can increase the risk of pulmo-nary embolism in lung cancer patients.Detecting these indicators,especially D-D levels,has important value in predicting the occurrence of pulmonary embolism in patients.关键词
肺癌/肺栓塞/碱性成纤维细胞生长因子/微小核糖核酸-1233/D-二聚体/纤维蛋白原Key words
Lung cancer/Pulmonary embolism/Basic fibroblast growth factor/Microribonucleic acid-1233/D-dimer/Fibrinogen分类
临床医学引用本文复制引用
解宝泉,王立民,王袁..肺癌患者bFGF、miR-1233、D-二聚体及Fib水平变化与肺栓塞发生的关系[J].疑难病杂志,2024,23(1):41-45,5.基金项目
河北省卫生健康委医学科学研究课题计划(20180781) Medical Science Research Project of Hebei Provincial Health Commission(20180781) （20180781）
