疑难病杂志2024，Vol.23Issue(1)：63-67,5.DOI:10.3969/j.issn.1671-6450.2024.01.011
NRG1、HER3在前列腺癌组织中的表达及其与临床病理特征和预后的关系
The expression of NRG1 and HER3 in prostate cancer tissue and their relationship with clinical pathological features and prognosis
摘要
Abstract
Objective To investigate the relationship between the expression of neuroregulatory protein 1(NRG1)and human epidermal growth factor receptor 3(HER3)in prostate cancer(PC)tissue and their clinical pathological character-istics and prognosis.Method Ninety-six PC patients diagnosed and treated in the urology department of Jilin Provincial People's Hospital from February 2015 to February 2020 were selected,and the expression of NRG1 and HER3 in the tissues was detected by immunohistochemistry;Kaplan Meier curve(Log Rank test)was used to compare the impact of different NRG1 and HER3 expressions on the prognosis of PC patients;COX regression analysis of prognostic factors in PC patients.Results The positive rates of NRG1 and HER3 in PC cancer tissues were 78.13％(75/96)and 75.00％(72/96),respectively,which were higher than those in adjacent tissues by 6.25％(6/96)and 8.33％(8/96)(χ2/P=101.670/<0.001,87.771/<0.001).TNM stage Ⅲ,Gleason score>7,and preoperative PSA level≥20 μ The positive rates of NRG1 and HER3 in cancer tis-sues of g/Lpatients werehigherthanthosein TNMstagingstages Ⅰ- Ⅱ,Gleasonscore≤7,andpreoperative PSAlevel<20 μ G/L(χ2/P=6.181/0.013,8.533/0.003;7.731/0.005,6.769/0.009;6.508/0.011,7.376/0.007).The 3-year cumulative progression free survival rates of the NRG1 positive group and HER3 positive group were lower than those of the NRG1 negative group and HER3 negative group,respectively(χ2/P=4.267/0.039,5.499/0.019).TNM stage Ⅲ,Gleason score>7,preoperative PSA≥20 μ G/L,NRG1 positivity,and HER3 positivity are independent risk factors affecting the prognosis of PC patients[OR(95％CI)=1.448(1.118-1.875),1.401(1.138-1.724),1.353(1.059-1.728),1.338(1.057-1.692),1.293(1.014-1.649)].Conclu-sion The increased expression of NRG1 and HER3 in PC cancer tissue is associated with adverse clinical and pathological features of PC,and is a new tumor marker for evaluating the prognosis of PC.关键词
前列腺癌/神经调节蛋白1/人表皮生长因子受体3/预后Key words
Prostate cancer/Neuromodulation protein 1/Human Epidermal growth factor receptor 3/Prognosis分类
医药卫生引用本文复制引用
王潇然,陆巍,于欣,王永杰,王勇,廉吉虎,李震霄,宋海涛..NRG1、HER3在前列腺癌组织中的表达及其与临床病理特征和预后的关系[J].疑难病杂志,2024,23(1):63-67,5.基金项目
吉林省中医药科技项目(2020194) Jilin Province Traditional Chinese Medicine Technology Project(2020194) （2020194）
