空军军医大学学报2024，Vol.45Issue(1)：35-38,4.DOI:10.13276/j.issn.2097-1656.2024.01.008
异种实体器官移植亚临床研究中的突破与问题
Breakthroughs and problems in subclinical research of solid organ xenotransplantation
摘要
Abstract
Solid organ xenotransplantation refers to an exploratory therapeutic technique in which solid organs such as heart,kidney,and liver from non-human donors are transplanted into human recipients.Currently,survival records of 2 to 3 years have been obtained in animal models of solid organ xenotransplantation of non-human primates derived from heterogenous gene-edited pig kidneys and hearts.Consequently,further improving the way and effect of gene editing and advancing xenotransplantation to clinical application has become a hot spot in organ transplantation.From 2021 to 2023,international research teams have conducted more than 10 subclinical studies on kidney and heart transplantation of gene-edited pig-to-brain-dead decedents,none of which showed hyperacute rejection.This paper reviews the results of 7 studies on subclinical xenotransplantation and 2 cases of pig heart transplantation reported in recent years,and discusses the problems to be solved in heart and kidney xenotransplantation,so as to provide some references for the clinical research of xenotransplantation in China.关键词
异种移植/非人灵长类动物/心脏移植/肾移植/排斥反应Key words
xenotransplantation/non-human primate/heart transplantation/kidney transplantation/rejection reaction分类
医药卫生引用本文复制引用
刘欣,杜嘉祥,淮国丽,邢向阳,谢雨宣,潘登科..异种实体器官移植亚临床研究中的突破与问题[J].空军军医大学学报,2024,45(1):35-38,4.基金项目
国家自然科学基金重大项目(32090054) （32090054）
