空军军医大学学报2024，Vol.45Issue(1)：39-42,47,5.DOI:10.13276/j.issn.2097-1656.2024.01.009
动物胸腺肾模型构建的现状及研究进展
Current status and research progress of animal thymokidney model construction
摘要
Abstract
Worldwide,for patients with end-stage organ failure,a major limitation of allogeneic organ transplantation is the shortage of donor organs.Xenotransplantation is a new research direction to solve the problem of organ shortage,but the rejection and virus infection after xenotransplantation are serious problems.Existing studies have shown that using thymus transplantation as an auxiliary means to construct animal thymokidney model during xenotransplantation can effectively reduce the occurrence of rejection.This paper mainly introduces the main characteristics of thymus,the construction of thymokidney model and the effect of thymokidney in establishing immune tolerance in xenotransplantation model.The thymokidney model was used to establish immune tolerance in 2 reported clinical trials of xenotransplantation,and the postoperative data showed that thymokidney could reduce rejection in clinical xenotransplantation.However,there is still no breakthrough in the research on the mechanism of immune tolerance of thymokidney,and more exploration is still needed in basic research in the future,in order to provide more precise theoretical basis for clinical application.关键词
异种移植/胸腺/胸腺肾/免疫耐受Key words
xenotransplantation/thymus/thymokidney/immune tolerance分类
医药卫生引用本文复制引用
王照翔,杨晓剑,秦卫军,魏凡超,黄大源,韩士超,戚若晨,王国辉,张小燕,刘克普,马帅军..动物胸腺肾模型构建的现状及研究进展[J].空军军医大学学报,2024,45(1):39-42,47,5.基金项目
国家自然科学基金(82102322) （82102322）
