不同比例的成分血输注对急性创伤性凝血病患者预后的影响OA

Objective To analyze the effect of different proportion component transfusion on prognosis of patients with acute traumatic coagulation disease(ATC).Methods Retrospective analysis of the medical records of 96 ATC patients who underwent transfusion in the region between January 2022 and January 2023.According to the blood transfusion ratio of different components,50 cases were divided into control group(infusion of suspended red blood cells and fresh frozen plasma according to 3:1 ratio)and 46 cases were divided into observation group(infusion of suspended red blood cells and fresh frozen blood according to 1:1 ratio).The blood products usage conditions were observed.Patient's treatment outcomes were appraised through the hemoglobin(Hb),blood platelet count(PLT),prothrombin time(PT),activated partial thromboplastin time(APTT),internal normalized ratio(INR),Fibrinogen(FIB)and D-dimer(D-D)levels;serum calcium ion(Ca2+)and potassium ion(K+)concentrations and clinical prognosis.Results There were no significant between-group differences about 24-hour red blood cell infusion volume,total red blood cell infusion volume,blood platelet infusion volume and cryoprecipitation infusion volume(P＞0.05);the plasma transfusion volume in the observation group was larger than control group,the difference was statistically significant(P＜0.05);before transfusion,Hb and PLT contents between groups were not significantly different(P＞0.05);after transfusion,Hb and PLT contents for two groups were increased(P＜0.05);but no significant differences were observed between groups(P＞0.05);before transfusion,PT,APTT,INR,FIB and D-D values between groups were not significantly different(P＞0.05);after transfusion,PT,APTT,INR,FIB and D-D values for two groups were reduced,PT,APTT and INR,FIB and D-D values in the observation group were even lower than control group,the difference was statistically significant(P＜0.05);before transfusion,Ca2+ and K+ concentrations between groups were not significantly different(P＞0.05);after transfusion,Ca2+and K+ concentrations for two groups were increased,the difference was statistically significant(P＜0.05);but no significant differences were observed between groups(P＞0.05);the cure rates in the observation group were higher than control group,the difference was statistically significant(P＜0.05);the uncured rate and mortality in the observation group were lower than control group,the difference was statistically significant(P＜0.05).Conclusion Compared with infusion of component blood at 3:1 ratio,infusion of component blood at 1:1 ratio can better improve coagulation function and improve prognosis of ATC patients.It is worthy of clinical application.