丁苯酞软胶囊联合替罗非班注射液治疗急性脑梗死的临床疗效OA
Clinical Effect of Butylphthalein Softgel Combined with Tirofiban Injection in the Treatment of Acute Cerebral Infarction
目的 探讨丁苯酞软胶囊联合替罗非班注射液治疗急性脑梗死的临床疗效.方法 选取 2019 年 12 月至 2022年 12 月于开封市中心医院治疗的急性脑梗死患者 60 例作为研究对象,通过随机数字表法将研究对象分为联合组、单药组各 30 例.联合组在采用丁苯酞软胶囊联合替罗非班注射液治疗,单药组使用替罗非班注射液治疗,对比单药组、联合组血管内皮功能指标[内皮素-1(ET-1)、一氧化氮(NO)]、炎性指标[白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(hs-CRP)]、血液流变学(全血还原黏度、低切还原黏度、高切还原黏度)、神经功能评分(NIHSS)、临床疗效及不良反应发生率.结果 治疗前两组ET-1、NO、IL-6、TNF-α、hs-CRP、全血还原黏度、低切还原黏度、高切还原黏度水平、NIHSS评分比较,差异无统计学意义(P＞0.05);治疗后两组ET-1、TNF-α、IL-6、hs-CRP、全血还原黏度、低切还原黏度、高切还原黏度、NIHSS评分水平均低于治疗前,NO水平均高于治疗前,差异具有统计学意义(P＜0.05);治疗后,联合组ET-1、TNF-α、IL-6、hs-CRP、全血还原黏度、低切还原黏度、高切还原黏度、NIHSS评分水平低于单药组,NO水平高于单药组,差异具有统计学意义(P＜0.05);联合组临床疗效优于单药组,差异具有统计学意义(P＜0.05);联合组不良反应发生率高于单药组,但差异无统计学意义(P＞0.05).结论 丁苯酞软胶囊联合替罗非班注射液治疗可提高临床疗效,改善血管内皮功能及神经功能,有效恢复患者脑血流灌注,降低炎性反应促进恢复,效果理想.
Objective To investigate the clinical efficacy of butylphthalein softgel combined with Tirofiban injection in the treatment of acute cerebral infarction.Methods A total of 60 patients with acute cerebral infarction treated in Kaifeng Central Hospital from December 2019 to December 2022 were selected as the study objects and the study objects were divided into a combination group and a single drug group with 30 cases each by random number table method.The combined group was treated with butylphthalein softgel combined with Tirofiban injection,and the monotherapy group was treated with Tirofiban injection.Vascular endothelial function indexes endothelin-1(ET-1),nitric oxide(NO),inflammatory indexes[interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),hypersensitive C-reactive protein(hs-CRP)],hemorheology(whole blood reductive viscosity,low reductive viscosity,high reductive viscosity),and national institute of health stroke scale(NIHSS),clinical efficacy and incidence of adverse reactions were compared between monotherapy group and combination group.Results Before treatment,there was NO statistical significance in ET-1,NO,IL-6,TNF-CRP,whole blood reductive viscosity,low reductive viscosity,and high reductive viscosity between the two groups(P＞0.05).After treatment,ET-1,TNF-α,IL-6,hs-CRP,whole blood reductive viscosity,low reduction viscosity,and high reduction viscosity were all lower than before treatment,and NO level was higher than before treatment,with statistical significance(P＜0.05).The clinical effect of the combination group was better than that of the single drug group,and the difference was statistically significant(P＜0.05).The incidence of adverse reactions in the combination group was higher than that in the single drug group,but the difference was not statistically significant(P＞0.05).Conclusion The combination of butylphthalein soft capsule and Tirofiban injection can improve clinical efficacy,improve vascular endothelial function and nerve function,effectively restore cerebral blood perfusion,reduce the inflammatory response,and promote recovery,and the effect is ideal.
朱丽娟;高营礼;张保华
开封市中心医院 神经内科二病区,河南 开封 475000
临床医学
丁苯酞软胶囊替罗非班注射液急性脑梗死
butylphthalein softgel capsulesTirofibaninjectionacute cerebral infarction
《临床研究》 2024 (002)
27-30 / 4
评论