原子与分子物理学报2024，Vol.41Issue(5)：9-16,8.DOI:10.19855/j.1000-0364.2024.051002
模型化研究药物小分子阻滞细胞周期
Modeling study of cell cycle arrest by small drug molecules
摘要
Abstract
Based on diffusion kinetics and cell signal transduction kinetics,we studied the cell cycle arrest char-acteristics of small drug molecules.The theoretical model takes into account the dynamic characteristics of the transport of small drug molecules across the cell membrane and the blocking effect of drug molecules entering the cell on the cell cycle.We found that the drug molecules crossing the inner layer of the cell membrane and ente-ring the cells will largely determine the blocking effect of drug molecules on related targeted genes and proteins.The transport characteristics of cell membrane to drug molecules are the key factors that affect drug molecules to block cell cycle.In addition,the degree of degradation of drug molecules will change the interaction time be-tween drug molecules and targeted genes and proteins,thereby changing the inhibitory effect on the growth and proliferation of related cells.By the sensitivity analysis of the parameters in the model,we confirmed the inhibi-tory effect of many factors in the process of drug molecules passing through the cell membrane and entering the cell on the cell cycle.The theoretical results in this paper are consistent with the simulation and experimental ob-servation,which further reveals the physical mechanism of drug small molecules blocking cell cycle,and can provide necessary references and new solutions for designing precise therapeutic drugs.关键词
药物分子/阻滞/细胞周期Key words
Drug molecules/Block/Cell cycle分类
数理科学引用本文复制引用
王凡,张菁菁,赵新军,蒋中英..模型化研究药物小分子阻滞细胞周期[J].原子与分子物理学报,2024,41(5):9-16,8.基金项目
国家自然科学基金(22163011) （22163011）
伊犁师范大学提升学科综合实力专项(22XKZY09) （22XKZY09）
