中风与神经疾病杂志2024，Vol.41Issue(1)：41-46,6.DOI:10.19845/j.cnki.zfysjjbzz.2024.0008
线粒体自噬对缺血性脑卒中的作用及其机制研究进展
Research advances in the role and mechanism of mitophagy in ischemic stroke
摘要
Abstract
As a type of selective autophagy,mitophagy is one of the key mechanisms for mitochondrial quality con-trol.Cerebral ischemia can trigger a variety of molecular cascade reactions,resulting in the accumulation of dysfunctional mitochondria.Mitochondrial dysfunction can induce the activation of mitophagy and maintain the homeostasis of neuronal cells by clearing damaged or depolarized mitochondria.Studies have shown that mitophagy is closely associated with the pathological process of ischemic stroke,but there are still controversies over its specific mechanism and role.This article reviews the mechanism of mitophagy and its role in ischemic brain tissue,so as to provide new ideas for the clinical treat-ment of ischemic stroke.关键词
脑缺血缺氧/线粒体自噬/炎症反应/氧化应激/程序性细胞死亡Key words
Cerebral ischemia and hypoxia/Mitophagy/Inflammatory response/Oxidative stress/Pro-grammed cell death分类
医药卫生引用本文复制引用
李婷婷,王钦鹏,刘晓庆,蔡珂,魏阳阳,梁成..线粒体自噬对缺血性脑卒中的作用及其机制研究进展[J].中风与神经疾病杂志,2024,41(1):41-46,6.基金项目
甘肃省科技厅自然科学基金(20210405JCC1549) （20210405JCC1549）
甘肃省神经病学重点实验室(20JR10RA766) （20JR10RA766）
