中风与神经疾病杂志2024，Vol.41Issue(1)：77-83,7.DOI:10.19845/j.cnki.zfysjjbzz.2024.0015
脂多糖破坏血脑屏障与脓毒症相关脑病发生的研究进展
Research advances in the mechanism of blood-brain barrier disruption by lipopolysaccharide and the onset of sepsis-associated encephalopathy
摘要
Abstract
As a barrier structure at the junction of the central nervous system(CNS)and the peripheral environ-ment,the blood-brain barrier(BBB)successfully separates the circulating blood in brain tissue from the CNS and strictly controls material exchange between circulating blood and brain tissue,such as the transport of nutrients and the expulsion of metabolic wastes,thereby maintaining the homeostasis of the CNS.Lipopolysaccharide(LPS)is a component of the cell wall of Gram-negative bacteria and can impair the barrier function of the BBB and further promote the development and pro-gression of sepsis-associated encephalopathy(SAE).This article reviews the mechanisms by which LPS injures the BBB via central links and other indirect links,as well as the association between these processes and SAE.We believe that when LPS causes damage to the BBB,a large number of immune cells and inflammatory factors enter brain tissue and acti-vate immune cells of the brain,and even the neurovascular units that make up the BBB are affected and mediate the re-sponses such as partial neuroinflammatory response and oxidative stress response,which causes further damage to the BBB.Such a vicious cycle eventually leads to the development of SAE,and therefore,we finally propose that targeted blockade of the disruption of BBB barrier function by LPS can be used for the prevention and treatment of SAE.关键词
血脑屏障/脂多糖/中枢神经系统/脓毒症相关脑病Key words
Blood-brain barrier/Lipopolysaccharide/Central nervous system/Sepsis-associated encepha-lopathy分类
医药卫生引用本文复制引用
刘平川,梅岚幸子,彭逍遥,杨粤凝,罗钰鼎,王建..脂多糖破坏血脑屏障与脓毒症相关脑病发生的研究进展[J].中风与神经疾病杂志,2024,41(1):77-83,7.基金项目
中央引导地方科技发展资金(2022ZYD0097) （2022ZYD0097）
四川省科技厅科研基金(2019ZYZF0063.2020YJ0497) （2019ZYZF0063.2020YJ0497）
四川省医学会青年基金(Q21049) （Q21049）
雅安市科技局科研基金(22KJJH0007) （22KJJH0007）
