中国防痨杂志2024，Vol.46Issue(2)：173-177,5.DOI:10.19982/j.issn.1000-6621.20230321
GeneXpert MTB/RIF检测技术在新疆结核病防治规划中的应用效果
The effect of GeneXpert MTB/RIF detection technology in tuberculosis prevention and control program in Xinjiang
摘要
Abstract
Objective:To explore the effect of using GeneXpert MTB/RIF("GeneXpert"for short)to detect pulmonary tuberculosis and rifampicin resistant pulmonary tuberculosis in the implementation of the"Xinjiang model"of tuberculosis prevention and treatment.Methods:The registration data of pulmonary tuberculosis in Xinjiang Uygur Autonomous Region("Xinjiang"for short)from 2017 to 2020 were collected from the"Tuberculosis Management Information System",a subsystem of the"China Disease Prevention and Control Information System",and the effect of the comprehensive application of GeneXpert detection was analyzed.The etiologically positive rate,rifampicin resistance detection rate,rifampicin resistance cases detected from 2017 to 2020 were evaluated.Results:The coverage rate,detection rate of GeneXpert devices,and overall etiologically positivity rate of all patients increased from 20.00％(22/110),0.32％(126/39 261),and 20.17％(7919/39 261)in 2017 to 100.00％(110/110),75.16％(19 610/26 090),and 57.94％(15 116/26 090)in 2020,respectively,and the differences were statistically significant(x2=40.705,P＜0.001;x2=174.087,P＜0.001;x2=47.569,P＜0.001).The number of etiologically positive patients increased from 7919 in 2017 to 15 116 in 2020,and the number of GeneXpert positive patients alone increased from 6 in 2017 to 7194 in 2020,accounting for an proportion from 0.08％(6/7919)to 47.59％(7194/15 116),with a statistically significant difference(x2=83.824,P＜0.001).The screening rate of rifampicin resistance and the resistance screening rate with GeneXpert in etiologically positive pulmonary tuberculosis patients increased from 44.49％(3523/7919)and 1.85％(65/3523)in 2017 to 99.79％(15 084/15 116)and 96.13％(14 501/15 084)in 2020,respectively,and the differences were statistically significant(x2=133.333,P＜0.001;x2=250.893,P＜0.001).Conclusion:The application of GeneXpert detection technology can significantly improve the detection level of etiologically positive and rifampicin resistant pulmonary tuberculosis cases,help the rapid decline of local tuberculosis epidemic in Xinjiang.关键词
结核,肺/利福平/抗药性/核酸扩增技术/对比研究Key words
Tuberculosis,pulmonary/Rifampin/Drug resistance/Nucleic acid amplification techniques/Comparative study分类
医药卫生引用本文复制引用
古丽娜·巴德尔汗,毕洪波,刘年强,伊帕尔·艾海提,王乐,王森路,祖力卡提阿衣·阿布都拉,王明哲,张静,王新旗..GeneXpert MTB/RIF检测技术在新疆结核病防治规划中的应用效果[J].中国防痨杂志,2024,46(2):173-177,5.基金项目
新疆维吾尔自治区卫生健康委青年医学科技人才专项科研项目(WJWY-202239,WJWY-202242) （WJWY-202239,WJWY-202242）
新疆维吾尔自治区科学技术协会青年人才托举工程项目(RCTJ42)Special Research Project for Young Medical Science and Technology Talents of the Health Commission of Xinjiang Uygur Autonomous Region(WJWY-202239,WJWY-202242) （RCTJ42）
Youth Talent Support Project of Xinjiang Uygur Autonomous Region Science and Technology Association(RCTJ42) （RCTJ42）
