中国感染控制杂志2024，Vol.23Issue(1)：112-118,7.DOI:10.12138/j.issn.1671-9638.20244581
SARS-CoV-2 S蛋白引起呼吸道上皮细胞炎症反应的研究进展
Advances in SARS-CoV-2 S protein-induced inflammatory response of respiratory epithelial cells
摘要
Abstract
Pneumonia caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection poses a threat to human life and health,resulting in great socio-economic losses.The structural protein spike protein(S protein)of viruses has always been considered to primarily mediate virus invasion into host cells.S protein can act independently of viruses and cause inflammatory reactions on a variety of cells,therefore,understanding the impact of S protein on the respiratory tract can provide a new perspective for the prevention and treatment of COVID-19.This article reviews the advances in the possible mechanisms and clinical manifestations of SARS-CoV-2 structural protein S protein-induced inflammatory response in respiratory epithelial cells,aiming to provide reference for the prevention and treatment of diseases.关键词
SARS-CoV-2/S蛋白/ACE2/呼吸道炎症Key words
SARS-CoV-2/S protein/ACE2/respiratory tract inflammation分类
医药卫生引用本文复制引用
刘兴健,张华华,张锐钢..SARS-CoV-2 S蛋白引起呼吸道上皮细胞炎症反应的研究进展[J].中国感染控制杂志,2024,23(1):112-118,7.基金项目
国家自然科学基金项目(82000008) （82000008）
