circDCUN1D4调节miR-18a-5p/FBP1轴对肺癌细胞增殖、凋亡和免疫逃逸的影响OACSTPCD
Effect of circDCUN1D4 on proliferation,apoptosis and immune escape of lung cancer cells by regulating the miR-18a-5p/FBP1 axis
目的 探讨环状RNA(circRNA)DCUN1D4调节微小RNA(miR)-18a-5p/果糖-1,6-二磷酸酶1(FBP1)轴对肺癌细胞增殖、凋亡和免疫逃逸的影响.方法 选取人肺癌细胞系(H1975、H1650、A549、SPCA-1)和人正常肺表皮细胞(HPL-1),qRT-PCR检测各种细胞中circDCUN1D4、miR-18a-5p、FBP1 mRNA表达水平.取对数生长期的A549细胞并分为空白组、circDCUN1D4过表达质粒(…查看全部>>
Objective To investigate the influences of circular RNA(circRNA)DCUN1D4 on the proliferation,apoptosis and immune escape of lung cancer cells by regulating the microRNA(miR)-18a-5p/fructose-1,6-bisphosphatase 1(FBP1)axis.Methods The human lung cancer cell lines H1975,H1650,A549 and SPCA-1 and human normal lung epidermal cells HPL-1 were selected,qRT-PCR was used to detect the expression levels of circDCUN1D4,miR-18a-5p and FBP1 mRNA in various cells.A549 cel…查看全部>>
史春辉;蔺建平;吴超
宝鸡市中医医院肿瘤科,陕西 宝鸡 721000宝鸡市中医医院呼吸与危重症医学科,陕西 宝鸡 721000西安国际医学中心医院呼吸内科,陕西 西安 710000
临床医学
circDCUN1D4miR-18a-5p/FBP1轴肺癌增殖凋亡免疫逃逸
circDCUN1D4miR-18a-5p/FBP1 axislung cancerproliferationapoptosisimmune escape
《局解手术学杂志》 2024 (1)
19-24,6
陕西省自然科学基础研究计划项目(S2021-JC-QN-2452)
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