局解手术学杂志2024，Vol.33Issue(1)：43-46,4.DOI:10.11659/jjssx.05E023051
调强放射治疗联合卡瑞利珠单抗治疗中晚期肝细胞肝癌的临床研究
Clinical study of intensity-modulated radiation therapy combined with camrelizumab in the treatment of advanced hepatocellular carcinoma
摘要
Abstract
Objective To investigate the efficacy and safety of intensity-modulated radiation therapy combined with camrelizumab in the treatment of advanced hepatocellular carcinoma(HCC).Methods A total of 84 patients with advanced HCC admitted to our hospital from January to December 2020 were selected as the study objects,and were randomly divided into the observation group and the control group,with 42 cases in each group.Patients in the observation group received intensity-modulated radiation therapy combined with carrelli-zumab,and patients in the control group received intensity-modulated radiation therapy.The short-term efficacy,immune function and long-term survival rate of patietns in the two groups were compared,and the incidence of adverse reactions was recorded.Results The total effec-tive rates of the observation group 1 month and 3 months after treatment were significantly higher than those of the control group(P<0.05).The levels of CD3+,CD4+ and CD4+/CD8+ 1 month and 3 months after treatment were all increased in the two groups,while the levels of CD8+ in both two groups were decreased(P<0.05),and the levels of CD3+,CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group(P<0.05),and the levels of CD8+ in the observation group were lower than those in the control group(P<0.05).The median survival time of patients in the observation group was significantly longer than that of patients in the control group(P<0.05).The incidence of cutaneous capillary hyperplasia in the observation group was higher than that in the control group(P<0.001),and there was no significant difference in the incidence of other adverse reactions between the two groups(P>0.05),and all of adverse reactions were grades 1 to 2.Conclusion Intensity-modulated radiation therapy combined with camrelizumab has a good effect on HCC,it can improve the immune function of the body,and control the development of the disease,with good safety.关键词
调强放射治疗/卡瑞利珠单抗/中晚期/肝细胞肝癌/临床疗效/安全性Key words
intensity-modulated radiation therapy/camrelizumab/advanced/hepatocellular carcinoma/clinical efficacy/safety分类
医药卫生引用本文复制引用
史广龙,徐学东,黄瑞,柴娜..调强放射治疗联合卡瑞利珠单抗治疗中晚期肝细胞肝癌的临床研究[J].局解手术学杂志,2024,33(1):43-46,4.基金项目
国家自然科学基金项目(81902488) （81902488）
