局解手术学杂志2024，Vol.33Issue(1)：73-76,4.DOI:10.11659/jjssx.02E023021
射波刀治疗肝癌对外周血淋巴细胞的影响
Effect of CyberKnife radiotherapy on peripheral blood lymphocytes of liver cancer
摘要
Abstract
Objective To explore the effects of different fractionation doses,fractionation methods,and other related parameters on the peripheral blood lymphocyte count of patients with liver cancer receiving CyberKnife radiotherapy.Methods The clinical data of 90 patients with liver cancer receiving CyberKnife radiotherapy in our hospital were retrospectively analyzed.The peripheral blood lymphocyte counts of patients 1 week before CyberKnife radiotherapy and 1 week,1 month and 3 months after treatment were determined.The effects of different prescribed doses,fractionation doses and numbers of fractionations on the peripheral blood lymphocyte count were analyzed.Results The peripheral blood lymphocyte counts of patients with different prescribed doses,fractionation doses and fractionation methods after CyberKnife treatment decreased to varying degrees compared with those 1 week before treatment(P<0.05).The peripheral blood lymphocyte counts of patients in the groups with≤5 fractionations and fractionation dose>7 Gy were significantly higher than those of patients in the groups with>5 fractionations and the fractionation dose≤7 Gy,respectively(P<0.05).There was no significant difference in peripheral blood lymphocyte counts between patients with different prescribed doses before and after CyberKnife treatment(P>0.05).Conclusion CyberKnife in the treatment of liver cancer with≤5 ractionations and a fractionation dose of>7 Gy is more beneficial to alleviate the decrease of lymphocyte count caused by Cyberknife treatment.关键词
肝癌/射波刀/淋巴细胞计数/免疫治疗Key words
liver cancer/Cyberknife/lymphocyte count/immunotherapy分类
医药卫生引用本文复制引用
傅华,魏莹,李莎,占海莉,牛冰冰,张超..射波刀治疗肝癌对外周血淋巴细胞的影响[J].局解手术学杂志,2024,33(1):73-76,4.基金项目
甘肃省自然科学基金项目(22JR5RA003) （22JR5RA003）
