局解手术学杂志2024，Vol.33Issue(1)：76-79,4.DOI:10.11659/jjssx12E022113
马来酸噻吗洛尔联合冷冻治疗婴幼儿皮肤血管瘤的临床研究
Clinical study of timolol maleate combined with cryotherapy for infantile cutaneous hemangioma
摘要
Abstract
Objective To explore the clinical effect of timolol maleate combined with cryotherapy for infantile cutaneous hemangioma.Methods A total of 240 infants with cutaneous hemangioma were randomly divided into the control group(120 cases)and the combined group(120 cases).The control group was treated with timolol maleate,and the combined group was treated with timolol maleate combined with cryotherapy.The clinical efficacy,tumor diameter,levels of serum matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)and the occurrence of adverse reactions of the two groups were compared.Results The total effective rate of the combined group was significantly higher than that of the control group(P<0.05).Compared with before treatment,the tumor diameter 3 months and 6 months after treatment in the two groups gradually decreased(P<0.05),and the tumor diameter 3 months and 6 months after treatment in the combined group decreased more obviously(P<0.05).Compared with before treatment,the levels of serum MMP-9 and VEGF 3 months and 6 months after treatment in the two groups gradually decreased(P<0.05),and the levels of serum MMP-9 and VEGF 3 months and 6 months after treatment in the combined group were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions such as eczema,ulcer,erosion or redness between the two groups(P>0.05).Conclusion Timolol maleate combined with cryotherapy for infantile cutaneous hemangioma has significant curative effect,which can effectively reduce the levels of serum MMP-9 and VEGF,and shrink the tumor body,with safety and effectiveness.关键词
婴幼儿皮肤血管瘤/冷冻疗法/马来酸噻吗洛尔/血管内皮生长因子/基质金属蛋白酶-9Key words
infantile cutaneous hemangioma/cryotherapy/timolol maleate/vascular endothelial growth factor/matrix metalloproteinase-9分类
医药卫生引用本文复制引用
张均秀,齐帅,高磊..马来酸噻吗洛尔联合冷冻治疗婴幼儿皮肤血管瘤的临床研究[J].局解手术学杂志,2024,33(1):76-79,4.基金项目
河北省卫生和计划生育委员会科研基金项目(20190186) （20190186）
