局解手术学杂志2024，Vol.33Issue(2)：125-128,4.DOI:10.11659/jjssx.01E023092
显微根尖手术联合引导骨再生技术治疗难治性根尖炎的临床疗效
Clinical effect of apical microsurgery combined with guided bone regeneration on refractory apical periodontitis
摘要
Abstract
Objective To investigate the clinical effect of apical microsurgery combined with guided bone regeneration(GBR)on refractory apical periodontitis and masticatory function.Methods A total of 82 patients with refractory apical periodontitis admitted to our hospital from June 2019 to September 2021 were selected as the study subjects,and they were divided into the control group and the com-bined group according to the random number table,with 41 cases in each group.The control group was treated with apical microsurgery,and the combined group was treated with apical microsurgery combined with GBR.The clinical efficacy,masticatory function and the levels of bone absorption markers[Wnt3a,osteoprotegerin(OPG),receptor activator of nuclear factor-κB ligand(RANKL)]of patients in the two groups were compared.Results The total effective rate of the combined group(100%)was higher than that of the control group(85.37%),the difference was statistically significant(P<0.05).The masticatory efficiency and bite force of patients in both groups increased gradually 3,6 and 12 months after operation(P<0.05),which were higher in the combined group compared with the control group(P<0.05).The tooth mobility of patients in both groups decreased gradually 3,6 and 12 months after operation,and the tooth mobility of patients 3 and 6 months after operation in the combined group were lower than those in the control group(P<0.05).The levels of Wnt3a and OPG of patients 1 week after operation in both groups increased,which were higher in the combined group compared with the control group(P<0.05).The RANKL level of gingival crevicular fluid of patients 1 week after operation in both groups decreased,and which was lower in the combined group compared with the control group(P<0.05).Conclusion The microapical surgery combined with GBR is effective for refractory apical periodontitis,which can effectively inhibit bone resorption,and improve masticatory function.关键词
显微根尖手术/引导骨再生技术/根尖炎/咀嚼功能/临床疗效Key words
apical microsurgery/guided bone regeneration/apical periodontitis/masticatory function/clinical efficacy引用本文复制引用
王宾,王俊艳,苗伟,朴维英,姚娜,靳泽斌,陈丽春..显微根尖手术联合引导骨再生技术治疗难治性根尖炎的临床疗效[J].局解手术学杂志,2024,33(2):125-128,4.基金项目
内蒙古口腔医学会临床科研基金项目(IMSA-2022-C2) （IMSA-2022-C2）
内蒙古自治区人民医院院内基金项目(2021YN07) （2021YN07）
