局解手术学杂志2024，Vol.33Issue(2)：137-140,4.DOI:10.11659/jjssx.01E023100
类风湿关节炎血清miR-410-3p表达与膝关节软组织病变的关系
Relationship between serum miR-410-3p expression and knee soft tissue lesions in patients with rheumatoid arthritis
摘要
Abstract
Objective To explore the expression of serum miR-410-3p in patients with rheumatoid arthritis(RA)and its relationship with knee soft tissue lesions.Methods A total of 89 RA patients admitted to our hospital were selected and divided into the active group(42 cases)and the remission group(47 cases)according to disease activity score in 28 joints(DAS28).In addition,52 healthy volunteers underwent physical examination during the same period in our hospital were selected as the healthy group.The expression level of serum miR-410-3p was detected by RT-PCR,the lesions of knee soft tissue was examined by ultrasound,and the relationship between the expression of serum miR-410-3p and knee soft tissue lesions was analyzed by Pearson.Results The expression levels of serum miR-410-3p of patients in the active group and the remission group were lower than that in the healthy group(P<0.05),and the expression level of serum miR-410-3p of patients in the active group was lower than that in the remission group(P<0.05).The cartilage thicknesses of medial and lateral ankle of patients in the active group and the remission group were smaller than those in the healthy group(P<0.05),and the above indexes in the active group were smaller than those in the remission group(P<0.05).The depths of suprapatellar bursa fluid and synovial thicknesses of patients in the active group and the remission group were greater than those in the healthy group(P<0.05),and the depth of suprapatellar bursa fluid and synovial thickness of patients in the active group were greater than those in the remission group(P<0.05).The level of serum miR-410-3p in RA patients was positively correlated with the depth of suprapatellar bursa fluid and synovial thickness(P<0.05),and negatively correlated with the cartilage thicknesses of medial and lateral ankle(P<0.05).Conclusion Serum miR-410-3p expression level in RA patients is decreased,which was closely related to knee soft tissue lesions,detecting the changes of serum miR-410-3p level may provide a reference for the evaluation of knee soft tissue lesions.关键词
类风湿关节炎/miR-410-3p/膝关节软组织病变Key words
rheumatoid arthritis/miR-410-3p/knee soft tissue lesions分类
医药卫生引用本文复制引用
饶慧,蒋盛芝,樊谕蓓,周雨晴,张丽华..类风湿关节炎血清miR-410-3p表达与膝关节软组织病变的关系[J].局解手术学杂志,2024,33(2):137-140,4.基金项目
长沙市科技计划项目(kq1901058) （kq1901058）
