局解手术学杂志2024，Vol.33Issue(2)：153-157,5.DOI:10.11659/jjssx.01E023048
超声造影联合血清SMURF1检测诊断甲状腺癌的临床分析
Clinical analysis of contrast-enhanced ultrasound combined with serum SMURF1 detection in the diagnosis of thyroid cancer
摘要
Abstract
Objective To investigate the diagnostic value of contrast-enhanced ultrasound(CEUS)combined with serum Smad ubiquitin regulatory factor 1(SMURF1)detection for thyroid cancer.Methods A total of 144 suspected thyroid cancer patients admitted to Lishui branch of Zhongda Hospital Affiliated to Southeast University from February 2019 to February 2020 were selected as the study subjects.Based on the histopathological results,they were divided into the thyroid cancer group(76 cases)and the benign group(68 cases).All patients underwent contrast-enhanced ultrasound examination and serum SMURF1 level detection;the diagnostic value of contrast-enhanced ultrasound parameters,serum SMURF1 detection alone,and the combination of the two methods for thyroid cancer were analyzed.Results Contrast-enhanced ultrasound parameters peak intensity(PI),mean perfusion intensity(SImean)and maximum perfusion intensity(SImax)in the thyroid cancer group were lower than those in the benign group,and the level of SMURF1 mRNA was higher than that in the benign group(P<0.05).The sensitivity of contrast-enhanced ultrasound parameter SImax in the diagnosis of thyroid cancer was 82.89%,the specificity was 72.06%,the accuracy was 77.78%,and the Kappa value was 0.552.The sensitivity of serum SMURF1 in the diagnosis of thyroid cancer was 65.79%,the specificity was 94.12%,the accuracy was 79.17%,and the Kappa value was 0.589.The sensitivity,specificity,accuracy and Kappa value of SImax combined with serum SMURF1 in the diagnosis of thyroid cancer were 97.37%,85.29%,91.67%and 0.832,respectively,which were higher than those of SImax and SMURF1 alone(P<0.05),the AUC of the combination of the two methods was 0.927,which was significantly higher than that of the two methods alone(Zcombined vs.SImax=3.999,P<0.001;Zcombined vs.SMURF1=3.270,P=0.001).Conclusion Contrast-enhanced ultrasound combined with serum SMURF1 detection can improve the diagnostic efficiency of thyroid cancer,which may avoid the over-diagnosis on the premise of ensuring the effective diagnosis of thyroid cancer patients.关键词
甲状腺癌/超声造影/Smad泛素调节因子1/诊断Key words
thyroid cancer/contrast-enhanced ultrasound/Smad ubiquitin regulatory factor 1/diagnosis分类
医药卫生引用本文复制引用
汪金,常新,韩春荣,万珂,谌辉,赵静,熊鹃..超声造影联合血清SMURF1检测诊断甲状腺癌的临床分析[J].局解手术学杂志,2024,33(2):153-157,5.基金项目
江苏省医院协会面上项目(JSYGY-3-2019-504) （JSYGY-3-2019-504）
江苏大学临床医学科技发展基金研究项目(JLY2021165) （JLY2021165）
2023年度江苏大学医教协同创新基金(JDYY2023101) （JDYY2023101）
