局解手术学杂志2024，Vol.33Issue(2)：170-174,5.DOI:10.11659/jjssx.03E023034
肝癌肝动脉化疗栓塞及肝动脉灌注化疗术后疼痛的治疗进展
Treatment progress of pains caused by transcatheter arterial chemoembolization and hepatic arterial infusion chemotherapy in hepatocellular carcinoma
摘要
Abstract
Conversion therapy such as transcatheter arterial chemoembolization(TACE)and hepatic arterial infusion chemotherapy(HAIC)is the main treatment method to transform unresectable advanced liver cancer into resectable liver cancer,which can not only effectively increase the survival rate of patients,but also provide patients with the opportunity of liver transplantation.However,pain is a major complication of TACE and HAIC in the treatment of liver cancer,and the incidence of abdominal pain after TACE is from 19.3%to 71.2%,and nearly 64.6%of patients have different degrees of pain during HAIC,which seriously affects the quality of life of patients and shortens their survival time.At present,the mechanism of pains caused by TACE and HAIC is not clear,and it may be related to local liver tissue swelling after embolic agents block the tumor blood supply artery,increased pressure in the liver tissue envelope or traction of the mass capsule,chemical stimulation of the hepatic artery by embolic agents and antineoplastic drugs,thrombosis adjacent to the normal organs,and visceral pain sensitization caused by intestinal ischemia.There are two main intervention measures for pain,one of which is lidocaine,opioids,non-steroidal anti-inflammatory drugs and glucocorticoids,and the other is wrist and ankle acupuncture and traditional Chinese medicine decoction,but their treatment effects are uneven.This article summarizes the status and treatment of pain caused by TACE and HAIC therapies for liver cancer,in order to provide reference for its clinical treatment.关键词
肝动脉化疗栓塞/肝动脉灌注化疗/疼痛/肝癌Key words
transcatheter arterial chemoembolization/hepatic arterial infusion chemotherapy/pain/liver cancer分类
医药卫生引用本文复制引用
贾贵鎣,黄燕,黄河,段光友,但伶..肝癌肝动脉化疗栓塞及肝动脉灌注化疗术后疼痛的治疗进展[J].局解手术学杂志,2024,33(2):170-174,5.基金项目
重庆市2018年科卫联合医学科研项目(2018ZDXM033) （2018ZDXM033）
