局解手术学杂志2024，Vol.33Issue(2)：179-182,4.DOI:10.11659/jjssx.07E023007
环状RNA参与卵巢癌铂耐药相关机制的研究进展
Research progress on the mechanism of circular RNA involved in platinum resistance in ovarian cancer
摘要
Abstract
Ovarian cancer has become the most lethal gynecological tumor due to the difficulty in early diagnosis,the late stage when diagnosed and the high recurrence rate.Resistance to platinum-based anti-tumor chemotherapy drugs is an important reason for the poor prognosis of ovarian cancer.circular RNA(circRNA)is more stable than mRNA in cells due to its special structure,and it is involved in the regulation of the occurrence,development and chemotherapy resistance of a variety of tumors.circRNA can be used as a competing endogenous RNA(ceRNA)of miRNA to bind to proteins,and regulates the phenotypic polarization of macrophages,it can also be used as an exosomal circRNA to regulate the sensitivity of platinum resistance in ovarian cancer.circRNA is expected to be a new marker of platinum resistance and a new target for the treatment of platinum resistance.In order to further explore the relationship between circRNA and platinum resistance in ovarian cancer,this article summarizes the recent literature related to circRNA and platinum resistance in ovarian cancer.关键词
环状RNA/卵巢癌/铂耐药/机制/综述Key words
circular RNA/ovarian cancer/platinum resistance/mechanism/review分类
临床医学引用本文复制引用
刘彬馨,范雅丹,吕春燕,梅子曼,邓青春..环状RNA参与卵巢癌铂耐药相关机制的研究进展[J].局解手术学杂志,2024,33(2):179-182,4.基金项目
2021年海南省自然科学基金高层次人才项目(821RC712) （821RC712）
2022年海南省重点研发计划项目(ZDYF2022SHFZ068) （ZDYF2022SHFZ068）
