摘要
Abstract
Objective To investigate the clinical efficacy and safety of triptorelin acetate combined with recombinant human growth hormone(rhGH)in the treatment of girls with central precocious puberty(CPP)of high skeletal age based on the hypothalamic-pituitary-gonadal(HPG)axis.Methods Girls with CPP were randomly divided into control group and treatment group.Control group was treated with intramuscular injection of 85-100 μg·kg-1 triptorelin acetate,once every 4 weeks,for 1 year.Treatment group was treated with triptorelin acetate combined with rhGH(subcutaneous injection of 0.12-0.20 U·d-1,qd,for 1 year).Clinical efficacy,growth and development indicators,Tanner stage of breast,uterine volume,ovarian volume,sex hormone levels,and adverse drug reactions were compared between the two groups.Results Excluding 8 drop-out cases,finally there were 42 cases in control group and 40 cases in treatment group.After 1 year of treatment,the total effective rate in treatment group was 90.00％(36 cases/40 cases),higher than 71.43％(30 cases/42 cases)in control group,with significant difference(P＜0.05).The height in treatment group and control group were(139.15±6.35)and(132.85±6.29)cm;growth velocity(ΔGV)were(8.35±0.52)and(5.14±0.45)cm;predicting adult height(PAH)were(159.74±4.61)and(157.39±4.22)cm,all with significant difference(all P＜0.05).The uterine volume in treatment group and control group were(2.39±0.59)and(3.51±0.68)cm3;ovarian volume were(1.11±0.25)and(1.43±0.55)cm3;estradiol(E2)levels were(18.25±6.33)and(23.54±7.61)U·L-1;luteinizing hormone(LH)levels were(1.07±0.26)and(1.93±0.38)U·L-1;follicle-stimulating hormone(FSH)levels were(0.66±0.12)and(1.07±0.34)pg·mL-1,the above indexes were significantly different between control group and treatment group(all P＜0.05).The total incidence rates of adverse drug reactions in treatment group and control group were 15.00％(6 cases/40 cases)and 14.29％(6 cases/42 cases),with no significant difference(P＞0.05).Conclusion The efficacy of triptorelin acetate combined with rhGH in the treatment of girls with CPP of high skeletal age is better.It can improve the girls'growth and development,lower the levels of sex hormones,and inhibit the secondary sexual characteristics,with good safety.关键词
中枢性性早熟/基于下丘脑-垂体-性腺轴/醋酸曲普瑞林/重组人生长激素/生长发育Key words
central precocious puberty/hypothalamic-pituitary-gonadal axis/triptorelin acetate/recombinant human growth hormone/growth and development分类
医药卫生
