中国临床药理学杂志2023，Vol.39Issue(24)：3664-3668,5.DOI:10.13699/j.cnki.1001-6821.2023.24.026
双特异性磷酸酶家族与胚胎发育的研究现状
Research status of dual-specificity phosphatase family and embryonic development
摘要
Abstract
Embryo development is the main stage of the formation of various tissues,organs and systems.Abnormal embryo development can lead to embryo deformity and even death.Many factors are involved in this process.It was found that dual-specificity phosphatase(DUSP)could regulate the growth and development of different cells through a variety of signaling pathways,and it has been confirmed that the DUSPs family has an important association with embryonic development.A large amount of evidences showed that DUSPs and its downstream mitogen-activated protein kinase(MAPK)pathway played a key role in the regulation of gametogenesis,digestive system development and embryonic ear development.dusp27 is another extremely important gene whose role in early embryonic development remains to be studied,but it plays an important role in the development of embryonic muscle tissue.In this paper,the development of the above systems in DUSPs family was briefly reviewed in order to provide theoretical basis for the treatment of embryonic developmental diseases.关键词
双特异性磷酸酶(DUSP)/胚胎发育/耳部发育/dusp27/肌肉组织Key words
dual-specificity phosphatase(DUSP)/embryo development/ear development/dusp27/muscle tissue分类
医药卫生引用本文复制引用
张冉,王经锁,陈亚芬,李沈蔚,张怀灿,纪威,王海英..双特异性磷酸酶家族与胚胎发育的研究现状[J].中国临床药理学杂志,2023,39(24):3664-3668,5.基金项目
国家自然科学基金青年基金资助项目(81703490) （81703490）
山东省医药卫生科技发展计划基金资助项目(202002061311) （202002061311）
济宁医学院教师科研扶持基金资助项目(JYFC2019KJ013) （JYFC2019KJ013）
济宁医学院大学生创新训练计划基金资助项目(cx2021053) （cx2021053）
